Calculating the total combinations of a Rubik's Cube involves understanding the mechanical constraints of the puzzle rather than simply multiplying the number of faces by the cubes on each face. The permutations include 8! for corner cube locations, 3^8 for their orientations, and additional factors for edge cubes, resulting in an astronomical total of 43 quintillion to 519 quintillion possible configurations. Most of these configurations do not lead to a solved state, as many are not achievable through legal moves. The complexity of the problem suggests that programming may not effectively count permutations due to the sheer size of the number. Understanding these constraints is crucial for accurately calculating the combinations of a Rubik's Cube.