Anybody here read Winfree "Geometry of Biological Time"?

In summary: There is a theorem on pg 27 that states that a continuous map from the disk (e.g. The area...or...the circumference) into the unit disk that does not have a singularity is the identity map.
  • #1
Jimster41
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I'm not sure I'm following the whole intro chapter 1C "Phase Singularities of Maps". Is he saying that the existence of an oscillator somehow requires a singularity?
 
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  • #2
He's talking about something much more specific than "the existence of an oscillator." He's talking about the properties of a continuous function from two input oscillators to a single output oscillator. He gives a topological argument about point(s) in phase space where the winding number of the output oscillator jumps discontinuously with small changes of the input phases.
 
  • #3
Thanks, @The Bill. Sorry my question was so vague. I was in a fugue of confusion/frustration.

So the paragraph right after he say's "there's a contradition coming..." is the one I've had to read 10 times - I'm struggling to grasp what the incompatibility of those three axioms (the first one modified to remove "almost", as he says) means.

1. a small change in phi A or phi B results in a small change in phi prime
2. phi A and phi B are interchangeable
3. when phi A or phi B are 0, phi prime is zero.

Firstly I don't quite get why the example/thought experiment needs two parents (phi A and phi B). Doesn't it work the same way if you have just phi A?
Secondly, this relates to difficulty I have had understanding how there can be a topology that cycles but is not contained in higher dimensional space in which the curvature that supports cycling/recursion is defined - in other words a strictly 2D+1 space (not a 2D+1 manifold in a 3D+1 space). In such a 2D+1 manifold an ant walking in a straight line returns to her point of origin because the 3rd dimension supports the curvature needed (the ant can experience no curvature - just the eventual return to her origin as she walks in a line). When you shrink that third dimension to nothing in an effort to do away with it I get to a conclusion that feels like what Winfree is talking about. When the size of that dimension goes to some shrinking limit the curvature has to be like what - infinite, undefined, paradoxical? The ant is standing there staring at her own butt? There is some intrinsic uncertainty? Yet if that dimension were zero - there could be no curvature and no cycle.
 
  • #4
A change in winding number isn't a small change. Far from singularities, small changes in the input phases doesn't change the winding number of the output. When the phase space trajectories are deformed in a way that crosses the singularity, the winding number can change.

Winding numbers for trajectories are just like a loop of string wrapped several times around an infinite solid rod, or a steel ring, or such. The winding number around the rod can't change without cutting and reattaching the string, or teleporting a hank of string discontinuously through the rod, etc.

If you haven't read it, Strogatz's "Nonlinear Dynamics And Chaos: With Applications To Physics, Biology, Chemistry, And Engineering" is an excellent broad based introduction to this topic, and has a very good discussion of winding numbers.
 
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  • #5
I read Strogatz's "Sync" which is a lightweight popularization but fascinating all the same. Reason I got Winfree's book.
The Bill said:
A change in winding number isn't a small change. Far from singularities, small changes in the input phases doesn't change the winding number of the output. When the phase space trajectories are deformed in a way that crosses the singularity, the winding number can change.

Winding numbers for trajectories are just like a loop of string wrapped several times around an infinite solid rod, or a steel ring, or such. The winding number around the rod can't change without cutting and reattaching the string, or teleporting a hank of string discontinuously through the rod, etc.

If you haven't read it, Strogatz's "Nonlinear Dynamics And Chaos: With Applications To Physics, Biology, Chemistry, And Engineering" is an excellent broad based introduction to this topic, and has a very good discussion of winding numbers.

I'm a bit confused by your reference to change in winding number. The point, I thought, is that the winding number is an integer. It's minimum value per change in the input phase must be 1 cycle and that really this thought puzzle is about the difficulty of having a map from a real to an integer while still assuming infinitesimal continuity. There is always a smaller move you can make with the input - which still must result in a minimum of 1 integer winding cycle. Or there is no non-zero change in the input that does not cause a minimum of one cycle.

Anyway thanks for the lead on that book. I will look for it.
 
  • #6
Actually I realize now there is a strong statement (Theorem) on pg 27

"The only continuous map from the disk (e.g. The area inside triangle αβγα) to the circle (the possible values of φ') have winding number 0 around the border of the disk. If the winding number cannot be zero (e.g., because of axiom 3), then the map cannot be continuous no matter what the underlying physical or biochemical mechanism might be. In fact no manifold can be retracted to its whole boundary while leaving that boundary point-wise fixed without a discontinuity appearing somewhere"

Wish I had a good grasp of what exactly "manifold retraction" means...

If I understand this correctly. My question then is what does the ubiquty of periodicity in nature suggest about its (nature's) fundamental support? Not that the converse of this theorem is given but the cause of periodicity at step 1 (aka quantum mechanics) must be given some mechanism. Winfree hints at the connection on pg 30 but leaves it there. From here I guess he's going to just go crazy on all the wonderful semi-empirical puzzles (because they are biological-observations as well as mathematics) that exist. But what an awesome start. Is he still around?
 
  • #7
Jimster41 said:
Wish I had a good grasp of what exactly "manifold retraction" means...

The first two pages of Hatcher's "Algebraic Topology" has a pretty good explanation of retractions. Plus, the book is available free as a PDF from the author's site: https://www.math.cornell.edu/~hatcher/AT/ATpage.html
 
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1. What is "Geometry of Biological Time" about?

"Geometry of Biological Time" is a book written by Arthur Winfree, a renowned mathematician and biologist. The book explores the concept of biological time and how it is related to geometry and mathematics. It also discusses various biological phenomena, such as circadian rhythms and cardiac rhythms, in relation to mathematical principles.

2. Who is the target audience for "Geometry of Biological Time"?

The book is primarily targeted towards scientists and researchers in the fields of biology, mathematics, and physics. However, it can also be a valuable resource for anyone interested in understanding the role of mathematics in biological systems.

3. What makes "Geometry of Biological Time" a groundbreaking book?

"Geometry of Biological Time" is considered groundbreaking because it was one of the first books to bridge the gap between biology and mathematics. It introduced the concept of "mathematical biology" and showed how mathematical principles can be applied to understanding biological systems.

4. Is "Geometry of Biological Time" a difficult read for non-mathematicians?

The book does contain complex mathematical concepts, but Winfree explains them in a clear and understandable manner. While some basic knowledge of mathematics may be helpful, the book is still accessible to non-mathematicians with an interest in biology.

5. How has "Geometry of Biological Time" influenced the scientific community?

"Geometry of Biological Time" has had a significant impact on the scientific community, particularly in the fields of mathematical biology and systems biology. It has inspired numerous research studies and has led to further exploration of the relationship between mathematics and biology.

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