What is linkage strength between gene loci?

In summary: In linkage, the probability of a recombination event between two loci is proportional to the distance between them.
  • #1
Tyto alba
62
0

Homework Statement


In linkage strength between any two gene loci is 70%,what would be the amount of crossing over between
these loci?

(a) 15% (b)30% (c) 70% (d) none of these.

2. My approach at understanding the concept

I didn't find much about linkage strength from any authentic source.
I can think of two things :
  • The strength of a linkage would be greater if the spatial separation between two genes is less and the lesser if the separation is more. This is semantic. But,
  • how can it be represented in percentage? What does this 100 mean in this 70%? The separation between two genes can be more than 100 map units.
3. Question in details

What does linkage strength mean? How is it related to amount of crossing over?

I would appreciate answers citing some authentic sources.
 
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  • #2
SanjuktaGhosh said:

Homework Statement


In linkage strength between any two gene loci is 70%,what would be the amount of crossing over between
these loci?

(a) 15% (b)30% (c) 70% (d) none of these.

2. My approach at understanding the concept

I didn't find much about linkage strength from any authentic source.
I can think of two things :
  • The strength of a linkage would be greater if the spatial separation between two genes is less and the lesser if the separation is more. This is semantic. But,
  • how can it be represented in percentage? What does this 100 mean in this 70%? The separation between two genes can be more than 100 map units.
3. Question in details

What does linkage strength mean? How is it related to amount of crossing over?

I would appreciate answers citing some authentic sources.

I suppose an authentic source would be the 600+ page 'Dictionary of Genetics'. It is not mentioned there. I have never heard the term used In a technical defined way; I suppose it can be used in a loose way io speaking. I do not understand how you can be asked such a question and are not supplied with a text that gives you a definition. I think genetic distances are usually expressed in centimorgans.

I would just answer 30% and wait to see if your Prof. gives an explanation.
 
  • #3
I think it is not a standard term too, if so Google would have shown some results. It was in a question paper, not a homework.

I also thought that way.
But using the word linkage strength to mean amount (proportion) of offspring with parental combination of genes is a bit strange.
 
  • #4
One usually hears of closeness of linkage rather than strength.
 

What is linkage strength between gene loci?

Linkage strength between gene loci refers to the degree of association or correlation between two or more genetic loci on a chromosome. It is a measure of how often these loci are inherited together, which can provide insight into their physical proximity on the chromosome and their possible functional relationship.

How is linkage strength measured?

Linkage strength is typically measured using a statistical measure called the linkage disequilibrium (LD) coefficient. This coefficient ranges from 0 to 1, with higher values indicating a stronger linkage between the loci. Additionally, the distance between the loci on the chromosome can also be used as a measure of linkage strength, with closer loci having a higher likelihood of being inherited together.

What factors influence linkage strength?

Several factors can influence linkage strength between gene loci, including the physical distance between the loci on the chromosome, the number of crossover events that occur during meiosis, and the amount of genetic recombination that takes place. Additionally, the strength of selection and genetic drift can also impact linkage strength.

Why is understanding linkage strength important?

Understanding linkage strength between gene loci is important because it can provide insight into the genetic architecture of a particular trait or disease. If two loci are highly linked, it suggests that they are physically close on the chromosome and may have a shared function. This information can help in identifying potential genetic targets for disease treatment and in predicting the likelihood of certain traits being inherited together.

How can linkage strength impact genetic studies?

The strength of linkage between gene loci can have a significant impact on genetic studies, such as genome-wide association studies (GWAS). Strong linkage between loci can make it difficult to identify the specific causative variant for a particular trait or disease, as multiple loci may appear to be associated. In contrast, weak linkage can make it easier to identify the specific genetic variant responsible for a trait or disease.

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