A quick followup of one thing I forgot to mention -- the same reagents (Ac2O/DMAP) in toluene remain clear after 2 hours at 100C, while the DMF solution has become brown.
Either this is an effect of the solvent polarity (no color in toluene vs. brown in DMF or acetone), or reaction of the...
Hi,
As part of my thesis research, I am trying to acetylate solid-supported secondary amines using acetic anhydride. I am doing this by a literature method, using 20% acetic anhydride in DMF with 1 mg/mL dimethylaminopyridine (DMAP) as a catalyst. The reaction takes place over a few hours at...