Medical Rise of Cancer: Examining the Role of Sugar and Refined Carbs

AI Thread Summary
Evidence is increasingly suggesting that the rise in sugar, high fructose corn syrup (HFCS), and refined carbohydrate consumption correlates with the increase in cancer incidence over recent decades. Discussions highlight the need for peer-reviewed studies to support these claims, with several links provided to relevant research. Participants debate the role of carbohydrates versus total caloric intake in obesity and related health issues, emphasizing the complexity of dietary impacts on health. The conversation also touches on historical trends in food processing and consumption patterns since the 1800s. Overall, the thread underscores the ongoing debate about the effects of refined carbohydrates on health, particularly concerning cancer and other diseases.
Siv
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I think evidence is increasingly suggesting that an explosion of sugar, HFCS and refined carb consumption has led to the huge increase in incidence of cancer in the past few decades.
 
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Evo said:
You will need to supply a study from a peer reviewed accepted mainstream scientific journal for this claim. Medical or scientific claims of this nature need documentation. Thanks.

http://www.ajcn.org/cgi/content/abstract/87/5/1384
http://www.ajcn.org/cgi/content/abstract/84/5/1171
http://www.ajcn.org/cgi/content/full/80/2/348
http://www.ajcn.org/cgi/content/abstract/86/5/1495
http://www.ajcn.org/cgi/content/abstract/86/4/899
http://www.ajcn.org/cgi/content/abstract/91/3/535

More and more evidence suggests carbs are the culprit, not fat - not just for cancer but diabetes, CHD and CVD. Please read "Good Calories, Bad Calories" by Gary Taubes for a ton of evidence, journal articles and references. Also read Dr. Bernstein, the Whole Health Source Blog, Heart Scan Blog and Panu.
 


Siv said:
http://www.ajcn.org/cgi/content/abstract/87/5/1384
http://www.ajcn.org/cgi/content/abstract/84/5/1171
http://www.ajcn.org/cgi/content/full/80/2/348
http://www.ajcn.org/cgi/content/abstract/86/5/1495
http://www.ajcn.org/cgi/content/abstract/86/4/899
http://www.ajcn.org/cgi/content/abstract/91/3/535

More and more evidence suggests carbs are the culprit, not fat - not just for cancer but diabetes, CHD and CVD. Please read "Good Calories, Bad Calories" by Gary Taubes for a ton of evidence, journal articles and references. Also read Dr. Bernstein, the Whole Health Source Blog, Heart Scan Blog and Panu.
Thanks Siv! That's more than I can read right now!
 


Siv said:
I think evidence is increasingly suggesting that an explosion of sugar, HFCS and refined carb consumption has led to the huge increase in incidence of cancer in the past few decades.

I don't see that increase in the chart I posted.
 


hamster143 said:
I don't see that increase in the chart I posted.
I would like to see the source for that last graph. URL please.

It would be interesting to see the trends from the 1800s onwards. Processed food has started coming in from the 1930s or so, right ? Soft drinks with HFCS, refined flour products with sugar and the tons of omega-6 fats in foods etc.
 


Siv said:
I would like to see the source for that last graph. URL please.

It would be interesting to see the trends from the 1800s onwards. Processed food has started coming in from the 1930s or so, right ? Soft drinks with HFCS, refined flour products with sugar and the tons of omega-6 fats in foods etc.

the increase in obesity isn't about carbs, it's about eating too many calories. Taubes is a fruitcake.
 


Siv said:
I would like to see the source for that last graph. URL please.

It would be interesting to see the trends from the 1800s onwards. Processed food has started coming in from the 1930s or so, right ? Soft drinks with HFCS, refined flour products with sugar and the tons of omega-6 fats in foods etc.

http://cancer2000.net/

HFCS specifically appeared in the United States around 1975, and it's still quite rare outside the US. But all it did was displace some sugar. Sugar consumption was high long before that. I can't find data for the US, but sugar consumption in the UK quadrupled between 1850 and 1900 and remained within 25% of the present level since then.

The USDA website has data on consumption of red meat (mainly beef & pork) in the US going back to 1909, and those levels also have been steady for the duration at ~100 lbs/person/year. Prior to that, there were some significant regional variations. Apparently Americans always ate plenty of meat, but, for example, mid-19th century Britons only averaged 20 lbs/person/year or so.

Refined flour seems to have come into existence (and then rapidly replaced whole wheat flour) around the same time, between 1850 and 1900.
 
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Proton Soup said:
the increase in obesity isn't about carbs, it's about eating too many calories. Taubes is a fruitcake.
Cute, that brought a smile to my face :)
But your statement is still an ad hominem cum opinion.

Dare I ask you to try and rebut the plethora of evidence in Taubes' book ?!
 


hamster143 said:
http://cancer2000.net/

HFCS specifically appeared in the United States around 1975, and it's still quite rare outside the US.
My mistake re: HFCS. BTW its started coming into food stores here.

But all it did was displace some sugar. Sugar consumption was high long before that. I can't find data for the US, but sugar consumption in the UK quadrupled between 1850 and 1900 and remained within 25% of the present level since then.

The USDA website has data on consumption of red meat (mainly beef & pork) in the US going back to 1909, and those levels also have been steady for the duration at ~100 lbs/person/year. Prior to that, there were some significant regional variations. Apparently Americans always ate plenty of meat, but, for example, mid-19th century Britons only averaged 20 lbs/person/year or so.

Refined flour seems to have come into existence (and then rapidly replaced whole wheat flour) around the same time, between 1850 and 1900.
Hmm. Interesting.
So maybe we should see the graph from the mid 1800s. All the sugar and refined carbs should have shown some increase in cancer, obesity and CVD/CHD rates.
I do remember someone on another forum presenting evidence that it rose when carb consumption rose and saturated fat consumption fell. Again, need time to dig that up.
 
  • #10


Siv said:
Cute, that brought a smile to my face :)
But your statement is still an ad hominem cum opinion.

Dare I ask you to try and rebut the plethora of evidence in Taubes' book ?!

i think we can start by recognizing that americans are fatter for a simple reason: we are eating more calories. it's a simple matter of energy balance. how much heavier do you suppose an average woman would have to be to support an extra 300 or so calories a day?

http://en.wikipedia.org/wiki/Diet_and_obesity#Average_calorie_consumption

i'll try to dig up some stuff on HFCS in the next day or two, but will mention a couple of things off the bat. the first is that HFCS, like sucrose (cane sugar) contains both glucose and fructose, in similar proportions. in fact, sucrose gets broken down in the stomach to exactly this.
http://en.wikipedia.org/wiki/Sucrose#Hydrolysis

and the whole reason you've got so much HFCS now is politics. we could have had tons of cane sugar imported cheaply from Cuba or Brazil, but our government has for a long time protected the US sugar cane industry. http://en.wikipedia.org/wiki/Hfcs

and there actually was a real issue with HFCS introducing mercury into the food supply early on, but none of this came to light until after the industry had already switched to acid/base reagents that aren't produced by mercury cell process. but that has nothing to do with glucose/fructose itself.
 
  • #11


Proton Soup said:
i think we can start by recognizing that americans are fatter for a simple reason: we are eating more calories. it's a simple matter of energy balance. how much heavier do you suppose an average woman would have to be to support an extra 300 or so calories a day?
That sounds nice but unfortunately, our body is far more complicated than that. The type of calorie matters hugely. The set points are different depending on whether your diet is high carb or low carb.

http://en.wikipedia.org/wiki/Diet_and_obesity#Average_calorie_consumption

i'll try to dig up some stuff on HFCS in the next day or two, but will mention a couple of things off the bat. the first is that HFCS, like sucrose (cane sugar) contains both glucose and fructose, in similar proportions. in fact, sucrose gets broken down in the stomach to exactly this.
http://en.wikipedia.org/wiki/Sucrose#Hydrolysis

and the whole reason you've got so much HFCS now is politics. we could have had tons of cane sugar imported cheaply from Cuba or Brazil, but our government has for a long time protected the US sugar cane industry. http://en.wikipedia.org/wiki/Hfcs

and there actually was a real issue with HFCS introducing mercury into the food supply early on, but none of this came to light until after the industry had already switched to acid/base reagents that aren't produced by mercury cell process. but that has nothing to do with glucose/fructose itself.

Tons of wiki quotes. Dont tell me wikipedia is now a peer reviewed journal ;)
HFCS has been proven to be more harmful than ordinary sucrose - please go to pubmed and do a search on HFCS.
 
  • #12


ViewsofMars said:
I doubt that. From the Office of Dietary Supplements - National Institutes of Health:

When your skin is exposed for a length of time, you burn in the sun if you don't wear sunscreen . I take a daily multi-vitamin and adhere to the dietary Guidelines from the Dietary Supplement Fact Sheet: Vitamin D :

How so? Give me a quote and the link (url) that supports your claim.
The RDA for Vitamin D is a joke. Hardly anybody tests their Vitamin D levels with a 25 hydroxy vitamin D blood test.

The Vitamin D council is a not-for-profit organization which has done tons of research on this. You should go to their website and read up on some of that.

Here are some links.

http://www.nature.com/jid/journal/v125/n5/full/5603599a.html
http://jn.nutrition.org/cgi/content/full/134/12/3472S
http://www.vitamin-d-deficiency-symptoms.com/does-sun-exposure-cause-skin-cancer.html[/URL]
[url]http://www.sciencedaily.com/releases/2010/10/101018162934.htm[/url]
 
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  • #14


Siv said:
That sounds nice but unfortunately, our body is far more complicated than that. The type of calorie matters hugely. The set points are different depending on whether your diet is high carb or low carb.

Tons of wiki quotes. Dont tell me wikipedia is now a peer reviewed journal ;)
HFCS has been proven to be more harmful than ordinary sucrose - please go to pubmed and do a search on HFCS.

oh, i will. and in the meantime, find me something from Taubes that is more than him just stating his opinion. most everything there on Pubmed attributed to G Taubes is either him commenting on a paper, or something for which he is the sole author, yet appears to simply open-ended comments.

the stuff on wikipedia is actually referenced btw, just follow the footnotes.
 
  • #15


Proton Soup said:
oh, i will. and in the meantime, find me something from Taubes that is more than him just stating his opinion. most everything there on Pubmed attributed to G Taubes is either him commenting on a paper, or something for which he is the sole author, yet appears to simply open-ended comments.
The whole book reads like pubmed. He references tons of studies and peer reviewed journals. So much so that the book is hard to get through sometimes.
Most people dismiss the book without even reading a few pages.
Same way religious folks do with Dawkins' books I guess :smile:

Plus its now being accepted by so many. More and more research indicates that saturated fat is not bad, that refined carbohydrates do harm in so many ways ...

Read up blogs by Dr William Davis, Dr Stephan Guyenet, Dr Kurt Harris, for starters.
 
  • #16


Siv said:
The whole book reads like pubmed. He references tons of studies and peer reviewed journals. So much so that the book is hard to get through sometimes.
Most people dismiss the book without even reading a few pages.
Same way religious folks do with Dawkins' books I guess :smile:

Plus its now being accepted by so many. More and more research indicates that saturated fat is not bad, that refined carbohydrates do harm in so many ways ...

Read up blogs by Dr William Davis, Dr Stephan Guyenet, Dr Kurt Harris, for starters.

i've read Davis' heartscanblog. he has some interesting intuition and observations. it was because of him that i switched to vitamin D in oil capsules instead of the calcium tablets. but he is not practicing science, it is the art of medicine. physicians give medical opinions. good observation and intuition may then lead some to do clinical studies, which are science.

and are you really going to bring up the paleo guys? man has been eating carbs for a http://www.wired.com/wiredscience/2010/10/revised-paleolithic-diet/" . some of us with say, european descent, have been drinking milk for so long that we can process it without getting lactose intolerance. that is an evolutionary adaptation beyond paleo. not to mention that we've lost the ability to synthesize vitamin C, which is a pretty good sign that we used to get a lot of carbs from fruit.

oh, speaking of vitamin C, this can lead to some funny things. like a paleo blogger http://www.carnivorehealth.com/main/2009/11/27/dry-fasting-its-gnarly-effects.html" . but hey, at least he learned from his mistake, which is a lot more than you can say about most of them.

but, where were we? oh yeah, pubmed! here, try this one on for size and tell me what you think.

http://www.ajcn.org/cgi/content/full/88/6/1716S"
Am J Clin Nutr. 2008 Dec;88(6):1716S-1721S.
Straight talk about high-fructose corn syrup: what it is and what it ain't.

White JS.

White Technical Research, Argenta, IL 62501, USA. white.tech.res@gmail.com
Abstract

High-fructose corn syrup (HFCS) is a fructose-glucose liquid sweetener alternative to sucrose (common table sugar) first introduced to the food and beverage industry in the 1970s. It is not meaningfully different in composition or metabolism from other fructose-glucose sweeteners like sucrose, honey, and fruit juice concentrates. HFCS was widely embraced by food formulators, and its use grew between the mid-1970s and mid-1990s, principally as a replacement for sucrose. This was primarily because of its sweetness comparable with that of sucrose, improved stability and functionality, and ease of use. Although HFCS use today is nearly equivalent to sucrose use in the United States, we live in a decidedly sucrose-sweetened world: >90% of the nutritive sweetener used worldwide is sucrose. Here I review the history, composition, availability, and characteristics of HFCS in a factual manner to clarify common misunderstandings that have been a source of confusion to health professionals and the general public alike. In particular, I evaluate the strength of the popular hypothesis that HFCS is uniquely responsible for obesity. Although examples of pure fructose causing metabolic upset at high concentrations abound, especially when fed as the sole carbohydrate source, there is no evidence that the common fructose-glucose sweeteners do the same. Thus, studies using extreme carbohydrate diets may be useful for probing biochemical pathways, but they have no relevance to the human diet or to current consumption. I conclude that the HFCS-obesity hypothesis is supported neither in the United States nor worldwide.

PMID: http://www.ncbi.nlm.nih.gov/pubmed/19064536" [PubMed - indexed for MEDLINE]

CONCLUSIONS

The hypothesis that HFCS is a unique cause of obesity is not supportable in the United States or elsewhere, and the reasons are clear:

  • HFCS has the same sugars composition as other "benign" fructose-glucose sweeteners such as sucrose, honey, and fruit juice concentrates and dietary sources such as fruits and juices;
  • Increased caloric intake since 1970 was not due to added sugars (including HFCS) but rather was due to increased consumption of all caloric nutrients, especially fats and flour and cereals;
  • HFCS is consumed in equal amounts with sucrose in the United States, but at <10% of the amount of sucrose worldwide;
  • Fructose-glucose sweeteners are metabolized through the same pathways regardless of dietary source;
  • Although pure fructose can cause metabolic upsets at high concentrations and in the absence of glucose, such experiments are irrelevant for HFCS, which is not consumed at extreme high levels and contains both fructose and glucose;
  • There is no longer an association between HFCS and obesity in the United States: per capita consumption of HFCS has declined in recent years, whereas obesity rates continue to rise; and
  • There is absolutely no association between HFCS use and worldwide obesity; HFCS is really a minor sweetener in the global perspective.
No one would disagree that HFCS as a caloric ingredient can lead to weight gain if products sweetened with it are consumed to excess. After all, the same may be said for all caloric ingredients, such as fats, protein, alcohol, and other carbohydrates. But there is absolutely no proof that HFCS acts in any exclusive manner to promote obesity. It is time to retire the hypothesis that HFCS is uniquely responsible for obesity. (Other articles in this supplement to the Journal include references 34-37.)
 
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  • #17


Proton Soup said:
i've read Davis' heartscanblog. he has some interesting intuition and observations. it was because of him that i switched to vitamin D in oil capsules instead of the calcium tablets. but he is not practicing science, it is the art of medicine. physicians give medical opinions. good observation and intuition may then lead some to do clinical studies, which are science.

and are you really going to bring up the paleo guys? man has been eating carbs for a http://www.wired.com/wiredscience/2010/10/revised-paleolithic-diet/" . some of us with say, european descent, have been drinking milk for so long that we can process it without getting lactose intolerance. that is an evolutionary adaptation beyond paleo. not to mention that we've lost the ability to synthesize vitamin C, which is a pretty good sign that we used to get a lot of carbs from fruit.
Ok. I post more than 8 links re: vitamin D, the damage of HFCS, sugar and refined carbs, their links to cancer etc ... and what have I got in response ?!

but, where were we? oh yeah, pubmed! here, try this one on for size and tell me what you think.

http://www.ajcn.org/cgi/content/full/88/6/1716S"
Umm... let me see. Did you read the entire article, right upto the end? I'm sure you did not miss this :wink:
ACKNOWLEDGMENTS

The author is a consultant to the food and beverage industry in nutritive sweeteners, including HFCS and sucrose. His professional associations, past and present, include individual food industry companies as well as such organizations as the American Chemical Society, American Council on Science and Health, Calorie Control Council, Corn Refiners Association, Institute of Food Technologists, and International Life Sciences Institute.

And this is not the only "study" sponsored by the food industry to try and do damage control to damaging evidence being revealed more and more. And all of them are available free full text :wink:

Now here you go re: the real evidence showing how bad HFCS really is.

http://www.ncbi.nlm.nih.gov/pubmed/19064538
http://www.ncbi.nlm.nih.gov/pubmed/19381015
Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
http://www.ncbi.nlm.nih.gov/pubmed/19208729
CONCLUSIONS: In obese subjects, consumption of fructose-sweetened beverages with meals was associated with less insulin secretion, blunted diurnal leptin profiles, and increased postprandial TG concentrations compared with glucose consumption. Increases of TGs were augmented in obese subjects with insulin resistance, suggesting that fructose consumption may exacerbate an already adverse metabolic profile present in many obese subjects.
 
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  • #18


Siv said:
Ok. I post more than 8 links re: vitamin D, the damage of HFCS, sugar and refined carbs, their links to cancer etc ... and what have I got in response ?!

Umm... let me see. Did you read the entire article, right upto the end? I'm sure you did not miss this :wink:


And this is not the only "study" sponsored by the food industry to try and do damage control to damaging evidence being revealed more and more. And all of them are available free full text :wink:

Now here you go re: the real evidence showing how bad HFCS really is.

http://www.ncbi.nlm.nih.gov/pubmed/19064538
http://www.ncbi.nlm.nih.gov/pubmed/19381015

http://www.ncbi.nlm.nih.gov/pubmed/19208729

actually, i don't find animal studies compelling at all. there are tons of diet supplements that have entered the market based on animal studies, and the problem is that they just don't work.

if you want to talk about conflict of interest, then you have to at least recognize that Taubes represents the goofball diet blogging industry, and everything he writes is to line his own pockets.

vitamin D is certainly interesting. i know Bill Davis found that in some of his patients that supplemental D had great effects on their lipid profiles. highly individual. maybe you should work with your doctor and see what works for you if you are hyperlipidemic.

and maybe most people should just work at not being fat and slothful, since that seems to be most peoples' problem.
 
  • #19


what the hell is this goofy crap? a hypercaloric diet that is 25% fructose? i guess it is true that goofy diets will get you goofy results.

J Clin Invest. 2009 May;119(5):1322-34. doi: 10.1172/JCI37385. Epub 2009 Apr 20.
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.

Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ.

Department of Molecular Biosciences, UCD, Davis, California 95616, USA.

Comment in:

* J Clin Invest. 2009 May;119(5):1089-92.

Abstract

Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.

PMID: 19381015 [PubMed - indexed for MEDLINE]


goofy studies aside, do you know how to get rid of visceral fat? it's easy, just exercise!
http://www.ncbi.nlm.nih.gov/pubmed/17637702
Int J Obes (Lond). 2007 Dec;31(12):1786-97. Epub 2007 Jul 17.
A dose-response relation between aerobic exercise and visceral fat reduction: systematic review of clinical trials.

Ohkawara K, Tanaka S, Miyachi M, Ishikawa-Takata K, Tabata I.

Health Promotion and Exercise Program, National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan. ohkawara@nih.go.jp

Erratum in:

* Int J Obes (Lond). 2008 Feb;32(2):395.

Abstract

OBJECTIVE: It has been suggested that exercise has preferential effects on visceral fat reduction. However, the dose-response effect remains unclear because of limited evidence from individual studies. The purpose of this study was to systematically review the current literature to establish whether reduction of visceral fat by aerobic exercise has a dose-response relationship.

METHODS: A database search was performed (PubMed, 1966-2006) with appropriate keywords to identify studies exploring the effects of aerobic exercise as a weight loss intervention on visceral fat reduction. Visceral fat reduction was expressed as the percentage of visceral fat change per week (%DeltaVF/w). The energy expenditure by aerobic exercise was expressed as Sigma (metabolic equivalents x h per week (METs x h/w)).

RESULTS: Nine randomized control trials and seven non-randomized control trials were selected. In most of the studies, the subjects performed aerobic exercise generating 10 METs x h/w or more. Among all the selected groups (582 subjects), visceral fat decreased significantly (P<0.05) in 17 groups during the intervention, but not in the other 4 groups. There was no significant relationship between METs x h/w from aerobic exercise and %DeltaVF/w in all the selected groups. However, when subjects with metabolic-related disorders were not included (425 subjects), METs x h/w from aerobic exercise had a significant relationship with %DeltaVF/w (r=-0.75). Moreover, visceral fat reduction was significantly related to weight reduction during aerobic exercise intervention, although a significant visceral fat reduction may occur without significant weight loss.

CONCLUSION: These results suggest that at least 10 METs x h/w in aerobic exercise, such as brisk walking, light jogging or stationary ergometer usage, is required for visceral fat reduction, and that there is a dose-response relationship between aerobic exercise and visceral fat reduction in obese subjects without metabolic-related disorders.

PMID: 17637702 [PubMed - indexed for MEDLINE]
 
  • #20


what the hell is this goofy crap? a hypercaloric diet that is 25% fructose? i guess it is true that goofy diets will get you goofy results.

I don't see the word "hypercaloric" in there. It shows that 25% of fructose in a diet have a statistically significant effect of reducing insulin sensitivity (in other words, predisposing the person to type 2 diabetes). A person on a high-carb diet with emphasis on simple carbs can easily exceed 25% and may even exceed 50%. What's goofy about that?
 
  • #21


Proton Soup said:
what the hell is this goofy crap? a hypercaloric diet that is 25% fructose? i guess it is true that goofy diets will get you goofy results.

A lot of problems with these 'fad' diets is they are based on "theory" and animal studies. Believe it or not, digestive enzymatic activity can vary greatly between species, even closely related ones.

Fructose for instance, enters the glycolytic pathway through an enzyme called fructokinase. Which has a very high Vmax and low Km. This means, it quickly phosphorylates fructose and is very active. Once phosphorylated the fructose cannot escape the cell, the bulky charge of the phosphates make lipid-insoluble.

The problem for humans, is that the next enzyme in this digestive pathway--Fructose-1-phosphate aldolase has a very high Km and very low Vmax. That is to say it's slow. Very slow.

So, fructokinase goes around burning up cellular stores of ATP, while the replenishment for ATP (continuing the digestion of fructose) is delayed. This leads to a decrease in intracellular ATP concentrations.

A funny thing happens. The decrease of ATP and increase of ADP signals the brain that you need more energy and you get hungry. Which would lead you to eat more and be counter-productive to the point of the "diet".

Interestingly, in medicine it was once thought that IV fructose maybe better than IV glucose and when given to patients they quickly developed high uric acid levels (from purine metabolism) and lactic acidosis--In severe patients fructose loading can even kill you.

People need to be less worried about "miracle" cures and one-stop diets and more worried with eating a balanced diet and getting off their behinds watching TV and being more active in their daily lives. American's (Westerner's even) extend the American dream (something for little or no effort) too far, in my opinion.

hamster143 said:
I don't see the word "hypercaloric" in there. It shows that 25% of fructose in a diet have a statistically significant effect of reducing insulin sensitivity (in other words, predisposing the person to type 2 diabetes). A person on a high-carb diet with emphasis on simple carbs can easily exceed 25% and may even exceed 50%. What's goofy about that?

Yes that's true, it will reduce your plasma insulin levels, because insulin production is dependent upon plasma glucose levels. But, as I point out above, at a trade off.

People seem to be on a hiatus against insulin these days. You're body is supposed to have and use insulin. If people would not take the lazy approach to their health (say like eating at Burger King 3 times a day) they wouldn't really need to worry about their insulin levels unless they were unlucky enough to inherit a genetic disease.
 
  • #22


People seem to be on a hiatus against insulin these days. You're body is supposed to have and use insulin. If people would not take the lazy approach to their health (say like eating at Burger King 3 times a day) they wouldn't really need to worry about their insulin levels

It's supposed to have insulin, sure ... but there's having insulin and there's having too much insulin. When you consistently consume a diet that contains the amount of fructose above safe levels, you develop insulin resistance, your fasting insulin and blood glucose levels go up, and at some point they get high enough that your condition is called "type 2 diabetes" with all the dangers it brings. That's exactly what causes diabetes, not eating at Burger King 3 times a day, but excess fructose. (Which is not to say that the two aren't interrelated: a single medium serving of non-diet soda at Burger King contains 40 grams of fructose.)

And then, due to the way fructose is metabolized, its regular overconsumption leads to fat deposits in the liver, which, when left unchecked by periodic fasting, lead to fatty liver disease (NAFLD) and potentially to a number of deadlier diseases such as cirrhosis and (back on the subject) liver cancer.
 
  • #23


hamster143 said:
I don't see the word "hypercaloric" in there. It shows that 25% of fructose in a diet have a statistically significant effect of reducing insulin sensitivity (in other words, predisposing the person to type 2 diabetes). A person on a high-carb diet with emphasis on simple carbs can easily exceed 25% and may even exceed 50%. What's goofy about that?

it was right here:
both groups exhibited similar weight gain during the intervention

you gain weight by eating more calories than you burn. that would be hypercaloric. if they had lost weight, it would be a hypocaloric diet.
 
  • #24


Proton Soup said:
it was right here:


you gain weight by eating more calories than you burn. that would be hypercaloric. if they had lost weight, it would be a hypocaloric diet.
If you assume what you want to conclude, then it becomes very easy, right ? :wink:

The whole point (actually one of the points) of really analyzing the real science in nutrition is that you realize that this simple calories in calories out theory is too simplistic and does not really explain anything. Plus its not true.
If your diet is high in carbs then your set point is much lower. And if your diet is high in fat/protein and low in carbs your set point is much lower.

Our body is far more complicated than the simplistic nonsense that had been spouted for so many decades.

And re: exercise, that was such a big myth that has been propogated for decades, again thanks to the so-called nutrition experts. Exercise does not help weight loss.

I am wondering whether it is worth debating with you. Not only do you not seem to know how to conduct rational debate and what is the type of evidence to look at, but your debating seems purely on opinion and confident assertions.

BTW if you have some sort of chip on your shoulder against me individually, hamster makes some good points.
 
  • #25


hamster143 said:
I don't see the word "hypercaloric" in there. It shows that 25% of fructose in a diet have a statistically significant effect of reducing insulin sensitivity (in other words, predisposing the person to type 2 diabetes). A person on a high-carb diet with emphasis on simple carbs can easily exceed 25% and may even exceed 50%. What's goofy about that?
Very true. Even fructose can easily exceed 25%. Easily.
Take a typical American diet. 1 pizza, 2 burgers, 5 diet sodas and maybe some processed chips like Lays. Do you know how much HFCS that is ?? Do the math.

The food and beverage industry has so much going for it, with the corn subsidies making HFCS such a big thing, that they are trying to do all that they can to discredit the evidence pouring in.

Forget the carb:fat ratio, if you just avoid all the processed crap available in dept stores and fast food restaurants today, I can bet my savings that cancer incidence will reduce drastically.
 
  • #26
Some more interesting articles.

http://www.time.com/time/health/article/0,8599,1914857,00.html

http://nymag.com/news/sports/38001/

Its surprising how we have accepted so many things as gospel without a shred of evidence.
 
  • #27


Siv said:
Take a typical American diet. 1 pizza, 2 burgers, 5 diet sodas and maybe some processed chips like Lays. Do you know how much HFCS that is ?? Do the math.

Um, zero? Or close to. Diet sodas don't contain any HFCS for sure. (Whether it's safe to consume that much aspartame, that's a different story). Domino's medium-sized "American Favorite Feast" pizza on deep dish crust is less than 4% simple sugars by weight; trust me, I just checked. A Big Mac contains 5 g of fructose. Lay's chips are also pretty much sugar free.

Bad example. :)

On the other hand, non-diet sodas, candies, cookies, donuts - that's where HFCS really gets pouring in. A single donut is typically 20 g or more of simple sugars. It's really hard to find healthy breakfast cereals: with a few exceptions, most of them are laced with HFCS (especially destructive, since they are marketed toward children). Sweetened Starbucks coffees are notorious about that, you can sometimes exceed 50 g in a single cup.
 
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  • #28


Oops, sorry. Meant ordinary sodas, the word diet was typed by mistake (sign o' the times, huh?!).
 
  • #29


Has anyone in this debate read any of

'The Saccharine Disease' by Cleave

or

'Tired or Toxic?' by Sherry Rogers

or

'Not on the Label' by Felicity Lawrence
 
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  • #30


Studiot said:
Has anyone in this debate read any of

'The Saccharine Disease' by Cleave
Um ... have you read the posts? That sugar and refined carbs are responsible for many of our current diseases/ailments is something that is definitely being discussed.
 
  • #31
Siv said:
Some more interesting articles.

http://www.time.com/time/health/article/0,8599,1914857,00.html

http://nymag.com/news/sports/38001/

Its surprising how we have accepted so many things as gospel without a shred of evidence.
Those are really terrrible articles. They take something that is true (and blindingly obvious) and twist it around to imply - completely incorrectly - that it's false, for the sake of sucking you into reading the article. Time does that all the time and IIRC, they got a huge amount of negative feedback for that article.

Exercise alone will make you lose weight.

That statement is true. It has to be. The human body's weight gain or loss is determined by the caloric balance: calories in - calories out = calories stored. If you increase the calories out while maintaining the calories in, you lose weight. Period.

What they are doing in those articles is applying faulty logic - and more importantly, faulty reading comprehension - to the thing that makes weight loss by exercise alone hard: when you exercise, your body demands more calories, so it is hard to not eat more. But look again at the statement in bold. Where in there does it addresses eating? It doesn't. It assumes all other factors including eating are held constant. So saying that the statement is wrong because exercise leads people to eat more is bad logic and bad reading comprehension.

The correct message that should be transmitted here is this: Exercise alone will cause you to lose weight, but it will cause you to want to eat more, so you have to be vigilant in maintaining your caloric intake. This really should not be hard to grasp, nor to do as long as you make yourself conscious of it. Eating habits are just that - habits. You should be able to control your caloric intake by eating what you normally do because you know what you normally eat. Ie, if you used to eat the "medium" extra value meal and now you're eating the "supersize", you're eating more. Obviously, this will cut into the weight loss, so you shouldn't do it.

Duh.

Here's a 5-part rebuttal:
The recent August 9th 2009 cover story from Time Magazine, "Why Exercise Won't Make You Thin" (Cloud, 2009) may be one of the most poorly researched and misrepresented articles about exercise and fitness. Not only did the author John Cloud misinterpret much of the exercise and health science literature--he has plenty of other articles where his seemingly lack of science and health knowledge is moot--and wrote an article that could potentially damage the public if they follow his misinformed advice, but Time Magazine has been completely irresponsible in publishing this article without seemingly proper fact checking. Cloud begins the article by touting his bitterness towards exercise and finds studies which seem to rationalize his disregard for proper exercise and nutrition. Cloud seems to lack comprehension in science, health, and fitness to accurately convey truthful information. The inaccurate and misleading conclusions he draws may make the metabolic syndrome (obesity, diabetes, heart disease, etc...) epidemic even worse if people believe his story.

http://www.examiner.com/diets-and-e...-why-exercise-won-t-make-you-thin-part-1-of-5
 
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  • #32


Um ... have you read the posts?

That sort of response makes me sorry I bothered to post at all.

Yes I checked electronically and according to my browser ,my post was the first mention of Dr Cleave in this thread.
 
  • #33


Siv said:
I am not so sure. Anthropologists who studied tribes untouched by the modern Western fast and processed food disease often did not find evidence for these.

References, please.

And given that Hippocrates described several cancers a couple thousand years ago (Moss, Ralph W. (2004). "http://www.cancerdecisions.com/speeches/galen1989.html" "), cancer is most certainly not caused by "the modern Western fast and processed food." Is there an increase caused by our diets? Possibly, although there are so many other factors out there including significantly changed levels of exercise and dietary composition, as well as exposure to sun, radiation, and man-made toxins, that's it's very difficult to definitively state cancers are due to x, y, or z.

peaking of dentists, anyone read Weston Price's work ? I don't mean the current WAPF, but the original works of Weston Price. Interesting stuff indeed.

I have Vols I & II of a rather thick medical text 1880's medical text which I find fascinating, both in terms of how much remains valid today, as well as how much was little more than heresay or anecdotal. They're in long-term storage, however. Otherwise, I'd share some tidbits!
 
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  • #34


Studiot said:
That sort of response makes me sorry I bothered to post at all.

Yes I checked electronically and according to my browser ,my post was the first mention of Dr Cleave in this thread.
Thats not what you asked, specifically about Dr Cleave.

What you did was post 3 books and asked if anyone had read them. The first book (which I referenced while replying) was one about the modern evils of refined carbs and sugar, which we have extensively discussed.
 
  • #35
Siv said:
Some more interesting articles.

http://www.time.com/time/health/article/0,8599,1914857,00.html

http://nymag.com/news/sports/38001/

Its surprising how we have accepted so many things as gospel without a shred of evidence.

good grief. and nowhere above did i post that exercise alone would make you thin. the points were simply this, that a surplus of calories will be stored as some kind of weight (often fat, but can also be muscle (which is almost always accompanied by fat, too, but let's not get into that)), and that exercise will burn visceral fat preferentially. visceral fat acts as more of a short-term storage depot. it's rather easy to get rid of, especially for a *ahem* paleo :rolleyes: guy that actually gets up off his rump to go find food instead of just driving to Publix.

for someone so concerned about gospels, it is a bit amusing to see you line up for the Flavor-Aid. anyhoo, i think i'll leave you to your delusions.
 
  • #36


russ_watters said:
Those are really terrrible articles. They take something that is true (and blindingly obvious) and twist it around to imply - completely incorrectly - that it's false, for the sake of sucking you into reading the article. Time does that all the time and IIRC, they got a huge amount of negative feedback for that article.

Exercise alone will make you lose weight.

That statement is true. It has to be. The human body's weight gain or loss is determined by the caloric balance: calories in - calories out = calories stored. If you increase the calories out while maintaining the calories in, you lose weight. Period.
Unfortunately, that's not true. Our body is far more complex than a simplistic calories in = calories out. The laws of theormodynamics are not violated (obviously!) but the set point changes depending on the type of calories.

For eg, if you feed 2 groups the same 2000 calories, but one where 80% are from carbs (mostly refined) and the other where 80% is fat, the 2 groups will gain different amounts of weight.

One simple factor is the energy the body uses in the digestion process, which is called the thermic effect of food. The thermic effect of protein is about twice that of carbohydrate or fat.

I will find the link later, but there was a study done at the City of Hope Medical Center in Duarte, California. Here they studied two groups of overweight people, both on medically supervised low-calorie liquid diets. One group added 3 ounces of almonds to their daily diet, while the other group added the same amount of calories from complex carbs like popcorn and Triscuit crackers. Both groups ate the same number of calories daily, about 1,000. During the 24-week study, the almond-eating group lost more weight even though they ate the same number of calories as the carb group.

There have been other studies done as well, I will need some time to dig them out.

Meanwhile, here's a nice article from Dr. Feinman
http://www.nutritionj.com/content/3/1/9

Quoting from the conclusion -
A review of simple thermodynamic principles shows that weight change on isocaloric diets is not expected to be independent of path (metabolism of macronutrients) and indeed such a general principle would be a violation of the second law. Homeostatic mechanisms are able to insure that, a good deal of the time, weight does not fluctuate much with changes in diet – this might be said to be the true "miraculous metabolic effect" – but it is subject to many exceptions. The idea that this is theoretically required in all cases is mistakenly based on equilibrium, reversible conditions that do not hold for living organisms and an insufficient appreciation of the second law. The second law of thermodynamics says that variation of efficiency for different metabolic pathways is to be expected. Thus, ironically the dictum that a "calorie is a calorie" violates the second law of thermodynamics, as a matter of principle.

Plus eating fewer than a certain threshold of calories puts your body in starvation mode and drastically reduces your metabolism too.

The correct message that should be transmitted here is this: Exercise alone will cause you to lose weight, but it will cause you to want to eat more, so you have to be vigilant in maintaining your caloric intake. This really should not be hard to grasp, nor to do as long as you make yourself conscious of it. Eating habits are just that - habits. You should be able to control your caloric intake by eating what you normally do because you know what you normally eat. Ie, if you used to eat the "medium" extra value meal and now you're eating the "supersize", you're eating more. Obviously, this will cut into the weight loss, so you shouldn't do it.

Duh.

Here's a 5-part rebuttal:

http://www.examiner.com/diets-and-e...-why-exercise-won-t-make-you-thin-part-1-of-5
Maybe this guy is a weirdo, but that does not matter. Resorting to ad hominem won't negative his evidence. And the evidence is there.

The Terry Wilkin study of childhood obesity, for e.g.
http://adc.bmj.com/content/early/2008/06/30/adc.2007.135012.abstract
There were no associations between physical activity and changes in any measure of body mass or fatness over time in either sex (e.g. BMI-SDS: r=-0.02 p=0.76). However, there was a small-to-moderate inverse association between physical activity and change in composite metabolic score (r=-0.19, p<0.01). Mixed effects modeling showed that the improvement in metabolic score among the more active compared to the less active children was linear with time (-0.08 z-scores/year, p=0.001).

Exercise is beneficial for lots of other things, but not weight loss.

Merely saying that if you starve and exercise you lose weight is no solution to anything. Its your bodies complicated homeostasis mechanism which makes you hungrier when you exercise. Which is what makes the calories in = calories out cliche a myth.

Exercise is not a useful method for weight loss. As Taubes says, the original Finnish report cited by most researchers for the benefit of exercise in weight loss is far from conclusive.
Yet the Finnish report, the most scientifically rigorous review of the evidence to date, can hardly be said to have cleared up the matter. When the Finnish investigators looked at the results of the dozen best-constructed experimental trials that addressed weight maintenance—that is, successful dieters who were trying to keep off the pounds they had shed—they found that everyone regains weight. And depending on the type of trial, exercise would either decrease the rate of that gain (by 3.2 ounces per month) or increase its rate (by 1.8 ounces). As the Finns themselves concluded, with characteristic understatement, the relationship between exercise and weight is “more complex” than they might otherwise have imagined.

The problem is that light exercise burns an insignificant number of calories, amounts that are undone by comparatively effortless changes in diet. In 1942, Louis Newburgh of the University of Michigan calculated that a 250-pound man expends only three calories climbing a flight of stairs—the equivalent of depriving himself of a quarter-teaspoon of sugar or a hundredth of an ounce of butter. “He will have to climb twenty flights of stairs to rid himself of the energy contained in one slice of bread!” Newburgh observed. So why not skip the stairs, skip the bread, and call it a day?
 
  • #37


Siv, there is a lot of confusion that seems to originate from differences in how much water people hold onto when they are on a keto diet, versus a higher carb diet that keeps them out of ketosis. people on a ketogenic diet can lose several kilograms of water weight, and unless you correct for this in your studies by doing something like a DEXA scan to measure body composition more directly, you're going to get screwy results. if you're just looking at a person's kg weight changes, then you don't really know what you're looking at. it is easy to misinterpret this as a change in "setpoint".
 
  • #38


Proton Soup said:
Siv, there is a lot of confusion that seems to originate from differences in how much water people hold onto when they are on a keto diet, versus a higher carb diet that keeps them out of ketosis. people on a ketogenic diet can lose several kilograms of water weight, and unless you correct for this in your studies by doing something like a DEXA scan to measure body composition more directly, you're going to get screwy results. if you're just looking at a person's kg weight changes, then you don't really know what you're looking at. it is easy to misinterpret this as a change in "setpoint".
Actually the Atkins water weight thing is just a myth.
http://community.discovery.com/eve/forums/a/tpc/f/634109964/m/8011922838

Anyway I am not recommending any diet here, but just acknowledging the real harm that refined carbs and sugars do. Apart from busting the exercise weight loss myth.
 
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  • #39


Siv said:
Actually the Atkins water weight thing is just a myth.
http://community.discovery.com/eve/forums/a/tpc/f/634109964/m/8011922838

Anyway I am not recommending any diet here, but just acknowledging the real harm that refined carbs and sugars do. Apart from busting the exercise weight loss myth.

no, it is not a myth. and the reason you gain water back on atkins is that atkins is only keto on the induction phase, and after you switch over to a more normal carb intake in later parts of the diet, the water comes back. have you read atkins? you realize it's got different phases and isn't the zero-carb caricature that the press makes it out to be?
 
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  • #40


Proton Soup said:
no, it is not a myth. and the reason you gain water back on atkins is that atkins is only keto on the induction phase, and after you switch over to a more normal carb intake in later parts of the diet, the water comes back. have you read atkins? you realize it's got different phases and isn't the zero-carb caricature that the press makes it out to be?
Ok, if you can skip the patronising assertions, maybe we can have a more productive debate ? :smile:
 
  • #42


Siv said:
Unfortunately, that's not true...

Exercise is not a useful method for weight loss.
You failed to address the point I made even a little bit. Besides the irrelevancies you disucssed, like the effects of different types of food (which may be interesting, but have nothing to do with exercise), you used the same logical disconnect as the article did! The fact that eating affects weight gain/loss does not in any way imply that exercise doesn't. The fact that eating less works better doesn't change the fact that exercising more still works. The fact that people who exercise more tend to start eating more doesn't change the fact that if they exercise more while holding their food intake steady they lose weight.

Again: Exercise alone can make you lose weight as long as you really are just adding exercise and not adding extra eating as well.

I think part of the disconnect is that what is the better way to lose weight is different for different people. For most it is a combination of the two, but for many people, the eating is the much bigger problem and therefore the much easier to correct. Example:
Many studies have compared weight loss resulting from changing diet versus increasing activity. Most often, weight loss during programs focused on dietary change produced two to three times greater weight loss than programs focused on exercise.
http://www.msnbc.msn.com/id/13821677/

That's easy to believe. Particularly if you're out of shape, it is very difficult to burn more than a few hundred (say 300) extra calories a day. But 300 calories a day is equal to only two sodas, and that's not a difficult thing to cut out of a diet.
 
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  • #43


Siv said:
Ok, if you can skip the patronising assertions, maybe we can have a more productive debate ? :smile:

very well. as for why atkins works (at least for some people), i think what you will find is that http://www.ajcn.org/cgi/content/full/87/1/44" . this results in people eating below their maintenance level of calories, they burn more than they eat, and start losing adipose mass. and because they also lose a lot of water in the beginning, the results appear more dramatic than they really are. losing adipose mass probably doesn't hurt your lipid profiles, either, as many people who unfat themselves find out.
 
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  • #44


russ_watters said:
You failed to address the point I made even a little bit. Besides the irrelevancies you disucssed, like the effects of different types of food (which may be interesting, but have nothing to do with exercise), you used the same logical disconnect as the article did!
Ok, very convenient way of dismissing all the info/links/research I presented.

I let moderator unpleasantness drive me away from PF once, but not again. I should have been able to develop a thick skin by now :wink:

Let me try again.

You said - "The human body's weight gain or loss is determined by the caloric balance: calories in - calories out = calories stored. If you increase the calories out while maintaining the calories in, you lose weight. Period."

To which I responded with - "Unfortunately, that's not true. Our body is far more complex than a simplistic calories in = calories out. The laws of theormodynamics are not violated (obviously!) but the set point changes depending on the type of calories.

For eg, if you feed 2 groups the same 2000 calories, but one where 80% are from carbs (mostly refined) and the other where 80% is fat, the 2 groups will gain different amounts of weight.

One simple factor is the energy the body uses in the digestion process, which is called the thermic effect of food. The thermic effect of protein is about twice that of carbohydrate or fat.

I will find the link later, but there was a study done at the City of Hope Medical Center in Duarte, California. Here they studied two groups of overweight people, both on medically supervised low-calorie liquid diets. One group added 3 ounces of almonds to their daily diet, while the other group added the same amount of calories from complex carbs like popcorn and Triscuit crackers. Both groups ate the same number of calories daily, about 1,000. During the 24-week study, the almond-eating group lost more weight even though they ate the same number of calories as the carb group.

There have been other studies done as well, I will need some time to dig them out.

Meanwhile, here's a nice article from Dr. Feinman
http://www.nutritionj.com/content/3/1/9

Quoting from the conclusion -
A review of simple thermodynamic principles shows that weight change on isocaloric diets is not expected to be independent of path (metabolism of macronutrients) and indeed such a general principle would be a violation of the second law. Homeostatic mechanisms are able to insure that, a good deal of the time, weight does not fluctuate much with changes in diet – this might be said to be the true "miraculous metabolic effect" – but it is subject to many exceptions. The idea that this is theoretically required in all cases is mistakenly based on equilibrium, reversible conditions that do not hold for living organisms and an insufficient appreciation of the second law. The second law of thermodynamics says that variation of efficiency for different metabolic pathways is to be expected. Thus, ironically the dictum that a "calorie is a calorie" violates the second law of thermodynamics, as a matter of principle.

Plus eating fewer than a certain threshold of calories puts your body in starvation mode and drastically reduces your metabolism too."


Re: your exercise claim, I responded to that with - "Maybe this guy is a weirdo, but that does not matter. Resorting to ad hominem won't negate his evidence. And the evidence is there.

The Terry Wilkin study of childhood obesity, for e.g.
http://adc.bmj.com/content/early/200...35012.abstract
There were no associations between physical activity and changes in any measure of body mass or fatness over time in either sex (e.g. BMI-SDS: r=-0.02 p=0.76). However, there was a small-to-moderate inverse association between physical activity and change in composite metabolic score (r=-0.19, p<0.01). Mixed effects modeling showed that the improvement in metabolic score among the more active compared to the less active children was linear with time (-0.08 z-scores/year, p=0.001).

Exercise is beneficial for lots of other things, but not weight loss.

Merely saying that if you starve and exercise you lose weight is no solution to anything. Its your bodies complicated homeostasis mechanism which makes you hungrier when you exercise. Which is what makes the calories in = calories out cliche a myth."


The fact that eating affects weight gain/loss does not in any way imply that exercise doesn't. The fact that eating less works better doesn't change the fact that exercising more still works. The fact that people who exercise more tend to start eating more doesn't change the fact that if they exercise more while holding their food intake steady they lose weight.
Please read what I wrote. I said that exercise was not a useful method for weight loss. Period.

Precisely because you cannot eat the same if you exercise more. Our body's homeostasis works to ensure that we compensate by eating more too. Artificially and forcefully starving yourself will never work long term and is not sustainable. What is far more likely to work is something which keeps you full and makes you less hungry.

Also, I don't agree that if you eat the same number of calories, the more you exercise, the more weight you will lose. Show me a study which shows this linear or geometric relation. I also contest that the type of food you eat will also affect how much you lose. As stated above, the laws of thermodynamics have been incorrectly interpreted for too long w.r.t nutrition and weight loss.
 
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  • #45


Here are some media articles debunking the calories in = calories out myth (the dumbing down of the complex mechanism of our bodies).

http://migraineur.wordpress.com/2007/11/11/calories-in-calories-out/

http://www.naturalnews.com/027126_dieting_food_health.html.
Quoting from above -
The idea of calories in versus calories out is a complete myth. The body is far more complex than that. There are hundreds upon hundreds of activities performed in your body at any given time - it needs fuel to perform these functions. If your body is not receiving the materials it needs from your diet, then it has no choice but to take from its only other source - itself. Most people assume your body will only use its stored fat for its various needs, but this is not true. Your body will also draw from your bones, muscle tissue and organ tissue. You may lose some fat, but it will be at the sacrifice of vital living tissues. This is not a good state to be in, so your body slows down your metabolism to prevent its own destruction. After all, your body has one natural instinct - to survive.


http://www.dummies.com/how-to/content/busting-the-great-myths-of-fat-burning.html.
A quote from the above :
Technically, once you've been exercising for 15 or 20 minutes, your body has made the shift to using a higher percentage of fat for fuel. But again, if you're trying to lose weight, it's about the total number of calories burned, not necessarily the fuel source.
For example, say that at rest you burn up to 60 percent fat. When you enter the initial phases of intense exercise, the ratio changes. You may now burn only 30 percent fat because your body is using quick-energy carbohydrates. Once the exercise is sustained, the body switches back to using a higher percentage of fat to fuel the movement (up to 75 percent fat). In this aerobic phase of exercise, a higher percentage of fat is being used for energy. But if you aren't working out for a very long period, you may still burn more total calories and, therefore, more fat calories working out harder. Put another way, if burning as many calories as you can is the best way to lose weight, even a dummy can figure out which activity of the following is going to give the best results (answer: jogging and sprinting), even though their fat-burning quota is on the low end of the ratio.
So you see, not only is it not a linear relationship, it depends on the type of exercise as well. Makes us realize how dangerous it is to oversimplify anything.
 
  • #46
Re: the water weight loss myth re: Atkins, here's an article which comprehensively debunks it.

http://www.diabeteshealth.com/read/2006/09/01/4838/losing-weight-on-a-lower-carb-diet/

Carbohydrates Can Cause Water Retention

Because stored glucose binds water, there is a diuretic effect during the first few days of the Induction phase of the Atkins Lifestyle, when carbs are limited to 20 grams daily. That’s why people on diuretic medications are cautioned when cutting carbs to do so with the supervision of their doctor to avoid overmedication.

For anyone following a lower-carb plan, it is important to stay properly hydrated. Most people do very well during the Induction stage. However, if help is needed to replace lost minerals because of an excessive loss of water, taking a multi-mineral every day or drinking two cups of salty broth daily works quite well for most people.

So its not that Atkins causes initial water weight loss but that high carb diets cause water retention.
Taubes also explains this beautifully in his book.
 
  • #47


Siv, please stop using blog articles to backup your assertions.
 
  • #48


These 2 are not blogs.
http://adc.bmj.com/content/early/200...35012.abstract
http://www.nutritionj.com/content/3/1/9

Plus some of these health blogs are a wealth of information. Run by really clever and qualified scientists/doctors who keep up to date with the latest research.

BTW was looking at the link you posted re: ketogenic diets. And it does not really support your case much.
The significantly (P = 0.006) greater weight loss with the LC diet (1.99 kg) than with the MC diet was due, in part, to the difference in water loss with the ketogenic diet, although this difference did not reach significance (0.71 kg; P = 0.158) (Table 4). There also tended to be greater losses of fat mass (1.05 kg; P = 0.083) and fat-free mass (0.94 kg; P = 0.054) with the LC diet than with the MC diet. In the 4-compartment model used, glycogen is considered part of the fat-free mass, and it cannot easily be directly measured. Examination of the change in protein mass (rather than in fat-free mass), calculated from the 4-compartment model, indicated that there was a weight loss of 0.25 and 0.02 kg with the LC ketogenic and MC nonketogenic diets, respectively (P = 0.281; SED: 0.202).
0.71 kgs ?? The margin of error would have been higher, that's why its not statistically significant.
 
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  • #49


Siv said:
These 2 are not blogs.
http://adc.bmj.com/content/early/200...35012.abstract
http://www.nutritionj.com/content/3/1/9

Plus some of these health blogs are a wealth of information. Run by really clever and qualified scientists/doctors who keep up to date with the latest research.

BTW was looking at the link you posted re: ketogenic diets. And it does not really support your case much.
0.71 kgs ?? The margin of error would have been higher, that's why its not statistically significant.

you know i specifically used that study for appetite suppression.

but if you want something with more significance, try this one: http://www.annals.org/content/140/10/769.full

if you want something really rigid (heavily controlled inpatient vs. outpatient), then this is interesting: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC333231/
 
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  • #50
When studying the effects of various interventions on human health, it is notoriously difficult to glean actionable information from anyone single scientific study. Often these are observational studies that are subject to many confounding factors and limited by small sample sizes, poorly controlled conditions, and short observation periods. Even well-controlled, randomized clinical trials can often reach opposing conclusions.

We can reach better conclusions, however, by performing a systematic literature review: examining the scientific literature as a whole by using strict criteria to select the highest quality studies and evaluating the results of the all of the studies as a whole. Although there may be individual studies within the review that support either side of an assertion, if a large majority of the studies support one side of an argument, we can be much more confident about their conclusions.

The 2007 report, Food, Nutrition, Physical Activity, and the Prevention of Cancer by the World Cancer Research Fund and American Institute for Cancer Research does just this. I will summarize the relevant findings of the review below. The full report is available here: http://www.dietandcancerreport.org/

Because obesity is an established cause of cancer, the report examined the risk factors for weight gain, overweight, obesity. The systematic literature review of this area covered 207 publications investigating the determinants of weight gain, overweight and obesity. The report concludes:

"The epidemiological evidence on physical activity is substantial and consistent. There is robust mechanistic evidence, particularly in relation to its impact on appetite regulation and energy balance. Overall, the evidence that all types of physical activity protect against weight gain, overweight, and obesity is convincing. It has this effect by promoting appropriate energy intake. Conversely, the evidence can be interpreted as showing that sedentary living is a cause of weight gain, overweight, and obesity."

The panel gives the evidence linking physical activity to a decreased risk of weight gain, overweight and obesity its highest ranking of convincing. The panel ranks the strength of evidence linking energy-dense foods, sugary drinks, and fast food to an increased risk of weight gain, overweight and obesity as probable.

Furthermore, while Siv has claimed that changes to appetite that accompany physical activity cancel the effects of exercise, the report claims otherwise:

"Control [of appetite] seems to be least effective at relatively low levels of physical activity, meaning that sedentary people tend to gain weight more readily than active people. Conversely, although high levels of physical activity increase energy requirements and appetite, the likelihood of consuming more than is needed is lower."

Therefore, although some may be able to produce studies showing otherwise, the preponderance of high quality scientific evidence strongly supports the assertion that physical activity can prevent weight gain, overweight and obesity.

Since this topic was originally on cancer, I will quote the panel's conclusions about the effects of sugar consumption on the risk for cancer:
"The evidence is hard to interpret. There is limited evidence suggesting that sugar is a cause of colorectal cancer."

This does not mean that there is convincing evidence that sugar is not a cause of cancer. Rather, the report concludes that there is not sufficient high quality evidence to reach a solid conclusion.
 
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