What is Graviity: Definition and 30 Discussions

Myasthenia gravis (MG) is a long-term neuromuscular disease that leads to varying degrees of skeletal muscle weakness. The most commonly affected muscles are those of the eyes, face, and swallowing. It can result in double vision, drooping eyelids, trouble talking, and trouble walking. Onset can be sudden. Those affected often have a large thymus or develop a thymoma.Myasthenia gravis is an autoimmune disease which results from antibodies that block or destroy nicotinic acetylcholine receptors (AChR) at the junction between the nerve and muscle. This prevents nerve impulses from triggering muscle contractions. Most cases are due to immunoglobulin G1 (IgG1) and IgG3 antibodies that attack AChR in the postsynaptic membrane, causing complement-mediated damage and muscle weakness. Rarely, an inherited genetic defect in the neuromuscular junction results in a similar condition known as congenital myasthenia. Babies of mothers with myasthenia may have symptoms during their first few months of life, known as neonatal myasthenia. Diagnosis can be supported by blood tests for specific antibodies, the edrophonium test, or a nerve conduction study.MG is generally treated with medications known as acetylcholinesterase inhibitors, such as neostigmine and pyridostigmine. Immunosuppressants, such as prednisone or azathioprine, may also be used. The surgical removal of the thymus may improve symptoms in certain cases. Plasmapheresis and high-dose intravenous immunoglobulin may be used during sudden flares of the condition. If the breathing muscles become significantly weak, mechanical ventilation may be required. Once intubated acetylcholinesterase inhibitors may be temporarily held to reduce airway secretions.MG affects 50 to 200 per million people. It is newly diagnosed in three to 30 per million people each year. Diagnosis is becoming more common due to increased awareness. MG most commonly occurs in women under the age of 40 and in men over the age of 60. It is uncommon in children. With treatment, most of those affected lead relatively normal lives and have a normal life expectancy. The word is from the Greek mys, "muscle" and astheneia "weakness", and the Latin gravis, "serious".

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  1. Mistenda

    Together, understanding the universe

    hobbyist, passionate studing of issues such as the nature of gravity, the LamdaCDM model, the dark matter, the dark energy, and the prevalence of ordinary matter over antimatter (baryogenesis)
  2. Priyo137

    Escape Velocity from Earth starting from its Centre

    What is the minimum velocity (theoretically) of an object located at the CENTER of the Earth to move it outside its gravitational field?
  3. SacCno

    B Help Scaling Gravity Simulation

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  4. N

    I Dropping an extended Slinky -- Why does the bottom of the Slinky not fall?

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  5. G

    How to find the equilibrium position of three masses (two of them fixed)?

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  6. L

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  7. C

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  8. I

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  9. TrentonF

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  10. M

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  11. Andy_K

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  12. Freonpsandoz

    I Gravitational Effects on Age of Earth's Core

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  13. J

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  14. T

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  15. J

    I Which object will hit the surface of a planet first?

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  16. T

    I How does the stress-energy tensor act on gravity?

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  17. BransonMO

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  18. xaratustra

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  19. A

    I Gravity well model going through a sphere

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  20. Y

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  21. menniandscience

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  22. B

    Forces on a plane exerted by a ball

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  23. A

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  24. B

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  25. G

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  26. Bunny-chan

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  27. ohwilleke

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  28. Ilguercino

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  29. MKP81

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  30. wolram

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