An Unsolvable Differential Calculus Problem: What is the Limit?”

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SUMMARY

The discussion centers on solving a differential equation related to the elimination of a substance from the body, represented by dx/dt = a - bx, where a and b are positive constants. The limiting concentration of the substance as time approaches infinity is established as x = a/b. Participants clarify the process of solving for the time it takes to reach half of this limiting concentration, emphasizing the need to rewrite the differential equation appropriately and apply the initial condition. The final solution for x(t) is given as x(t) = a/b + (x0 - a/b)e^(-bt).

PREREQUISITES
  • Understanding of differential equations, specifically first-order linear equations.
  • Familiarity with exponential functions and their properties.
  • Basic knowledge of biological applications of calculus, particularly in pharmacokinetics.
  • Ability to manipulate initial conditions in mathematical equations.
NEXT STEPS
  • Study the method of solving first-order linear differential equations.
  • Learn about pharmacokinetics and the mathematical modeling of drug elimination.
  • Explore the concept of limits in calculus, particularly in biological contexts.
  • Investigate the use of exponential decay functions in real-world applications.
USEFUL FOR

Students in mathematics or biology, particularly those studying pharmacokinetics, as well as educators and professionals seeking to understand the application of differential calculus in biological systems.

laminar
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This is biological application question, so the limit can't be negative infinity, which is what I would use as my answer for a regular question.

The rate at which substance is eliminated from the body is proportional to the amount of substance present, and satisfies the differentail equation dx/dt=a-bx, where a and b are positive constants. What is the limiting concentration of substance(limit as t goes to infinity of x(t))?

Can't integrate for this because it's a course on differential calculus only. Any pointers?
 
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Well, what is the rate of change of the amount once the amount has reached a constant level?
 
Rate of change is zero... So, x=a/b when the limiting concentration is reached. What do I do with this?

Thank you for replying so fast
 
Well, so what is then the limiting concentration you were asked about?
 
laminar, the rate of change is zero as t goes to infinity (this should be intuitive).
 
But then another part of the question asks the time it takes to reach half of the limiting concentration... I'm lost.
 
You DO know that the solution of the diff.eq f'=af for some constant f is an expontential function, right?
 
Yes, I know that I would find the time by x=x0e^kt.
 
laminar said:
Yes, I know that I would find the time by x=x0e^kt.
No, you don't, because your diff.eq is slightly different!
First, do the following rewriting of your diff.eq:
\frac{dx}{dt}=-b(x-\frac{a}{b})
with initial condition: x(0)=x_{0}

Then, introduce the new variable y(t)=x(t)-\frac{a}{b}\to\frac{dy}{dt}=\frac{dx}{dt}[/tex]<br /> <br /> Thus, your diff.eq can be written as:<br /> y(t)=-by(t)\to{y}(t)=Ae^{-bt}\to{x}(t)=\frac{a}{b}+Ae^{-bt}<br /> where A is a constant to be determined by the initial condition:<br /> x_{0}=x(0)=\frac{a}{b}+A\to{A}=x_{0}-\frac{a}{b}<br /> <br /> Therefore, your solution is:<br /> x(t)=\frac{a}{b}+(x_{0}-\frac{a}{b})e^{-bt}<br /> <br /> Now, you are to find the time T, so that x(T)=\frac{x_{0}}{2}<br /> <br /> We therefore have to solve the following equation for T in terms of the other parameters:<br /> \frac{x_{0}}{2}=\frac{a}{b}+(x_{0}-\frac{a}{b})e^{-bT}<br /> Can you do that?
 
  • #10
I'm sorry. I thought the question was to find the time T so that you have half the INITIAL concentration.
In order to find the time t* to half the limiting concentration, adjust the last step accordingly.
 
Last edited:
  • #11
Ah, much thanks. Forgive me, I'm an arts student taking math courses.
 
  • #12
Arts or no arts, have you found your answer now?
 
  • #13
Yeah I get how to find t, but I still don't get how to find the limiting concentration.
 

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