Is there a general average number of neurotransmitters a given cell would "work with"?
Most neurons, for input, are influenced by a variety of different neurotransmitter species (namely, glutamate, GABA, the monoamines, and others) but project only a single neurotransmitter via their axon as output.Is there a general average number of neurotransmitters a given cell would "work with"?
What I mean is that, if we look at a typical pyramidal neuron is the cerebral cortex, we see that, on average, it receives about 10,000 pre-synaptic inputs on it's apical dendrites from input neurons coming mainly from the thalamus or other regions of the cortex. The typical method of signaling between neurons through the synaptic cleft is for the pre-synaptic bouton to release synaptic vesicles. Each vesicle contains about 10,000 neurotransmitter molecules so, if you do the math, it's well into the millions or even billions of actual molecules that participate in any given action potential. However, again, the number can vary dramatically depending on the balance of inhibitory and excitatory species competing at any given time instant.Hmm. Glutamate is known to cause spill-over synaptic crosstalk. That what you mean by 'more than hundreds or thousands ...'?