COVID Boost Response by Delaying Second Dose -- Pfizer vaccine in elderly

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The Pfizer vaccine shows increased peak antibody levels in older individuals who wait 11–12 weeks for their second dose, compared to those who receive it after 3 weeks. This extended interval could enhance antibody responses significantly, especially in those over 80. Despite the high efficacy of the vaccine in older populations, with real-world data indicating 95% protection for those over 70, delaying the second dose may not substantially improve overall protection. Concerns exist that a longer wait could lead to increased disease risk before the second dose is administered. Future vaccine designs might benefit from this data, potentially allowing for lower doses and longer intervals to maintain efficacy while minimizing side effects.
Tom.G
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This applies to the Pfizer vaccine. Article dated May 13, 2021.

https://www.nature.com/articles/d41586-021-01299-y

Older people who waited 11–12 weeks for their second jab had higher peak antibody levels than did those who waited only 3 weeks. ...could boost antibody responses after the second inoculation more than threefold in those older than 80. (bold added)

Cheers,
Tom
 
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The Pfizer vaccine has already been observed to be very effective in older individuals (the original Phase III trial observed a 100% vaccine efficiency for those >75 (though this was based on a fairly low # of people) and real world data from Israel indicated a 95% protection for those > age 70. So, delaying the second dose probably would not increase protection very much (hard to do much better than 95% protection) and could actually lead to more disease if the protection before the second dose in weeks 3-11 is not effective as the protection from getting a second dose at week 3.

However, this data could be useful in designing vaccines going forward. For example, future vaccines might be able to use a lower dose of vaccine (which would hopefully have lower side effects) with greater spacing to achieve similar levels of protection.
 
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