Can We See Atoms and Molecules Without High Powered Microscopes?

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Discussion Overview

The discussion revolves around the possibility of visualizing atoms and molecules without relying solely on high-powered microscopes. Participants explore various methods and technologies related to microscopy and the limitations of different approaches in observing nanoscale objects.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • One participant questions whether "seeing" refers to visualizing with the naked eye or using alternative instruments to high-powered microscopes.
  • Another participant states that atomic force microscopy has been used to capture images of molecules, indicating that atoms are difficult to visualize.
  • A different viewpoint suggests that optical microscopes can detect materials that are one atomic layer thick, using graphene as an example of observable contrast.
  • Another participant mentions that interferometric microscopes can measure height contrasts down to 0.1 nm, but this is limited to atomic layers rather than individual atoms.
  • Progress in fluorescence techniques, such as STED, PALM, and STORM, is noted as a significant advancement in differentiating between atoms.

Areas of Agreement / Disagreement

Participants express differing opinions on the capabilities of various microscopy techniques and whether alternative methods can effectively visualize atoms and molecules. No consensus is reached regarding the best approach or the definition of "seeing" in this context.

Contextual Notes

Limitations include the ambiguity in the definition of "seeing" and the varying capabilities of different microscopy techniques, which depend on specific conditions and materials being observed.

viciam
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Hi guys,

I hope you don't mind me posting here, I am doing some research into atoms, molecules and microscopes. I have no knowledge of physics, the quantum world or microscopy so if my questions seem silly, please look past that and help me. Thank you

I have two questions. Is there a way to see atoms, molecules and other nanoscale objects other than through high powered microscopes?

And another question is, what are your thoughts on the FEI company microscopes? Have you used them? Would you recommend them?

Thanks in advance
 
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viciam said:
I have two questions. Is there a way to see atoms, molecules and other nanoscale objects other than through high powered microscopes?

Define "see". Are you asking for the ability to view these things with our naked eyes, without the use of any other instruments? Or are you asking if there are OTHER instruments that can be used besides "high powered microscopes"?

Zz.
 
Last edited:
You can, however, see things that are only one atomic layer thick in an optical microscope.
This becomes fairly obvious if you look at graphene, there is actually optical contrast between single and bilayer graphere, even though the difference in thickness is much less than the wavelength of the light (and you can also see the contrast between the single layer graphene and the substrate).
It is a nice -and very useful- optical effect.
(I should point out that the effect is much easier to see if you use a camera where you can adjust the contrast)
 
Interferometric microscopes can measure height contrasts down to 0.1 nm, however this can only be applied to atomic layers and not single atoms. The lateral resolution of interferometric microscopes is still the usual ~wavelength/2.

That said, enormous progress has been made in the past decade using fluorescence to differentiate between atoms. Look up the work of Stefan Hell and techniques like STED, PALM, STORM etc.

Claude.
 

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