From the wiki page on Hermann von Helmholtz: "an 1847 physics treatise on the conservation of energy was written in the context of his medical studies and philosophical background. He discovered the principle of conservation of energy while studying muscle metabolism. He tried to demonstrate that no energy is lost in muscle movement, motivated by the implication that there were no vital forces necessary to move a muscle. This was a rejection of the speculative tradition of Naturphilosophie which was at that time a dominant philosophical paradigm in German physiology." What were these 'vital forces' and what was the paradigm at that time? How would this lead to CoE?