trainman2001 said:
If cold virus Coronavirus mitigate severity of COVID 19, could the inverse be true also; that COVID vaccines could provide some protection against some of the common cold varieties?
It seems plausible. See the paper by Penaloza-MacMaster and colleagues. I think it depends on how conserved various parts of the viruses are, and which parts of the viruses are used in making the vaccines. There's also related work about trying to make a vaccine that protects broadly against subtypes of coronaviruses.
https://www.the-scientist.com/news-opinion/the-quest-for-a-universal-coronavirus-vaccine-68934
"Penaloza-MacMaster and his colleagues ... In mice, they demonstrated that various SARS-CoV-2 vaccines, including mRNA vaccines such as the shot from Pfizer/BioNTech and viral-vector vaccines such as Johnson & Johnson’s version, generated immune responses against SARS-CoV-1 and OC43.
...
viral vector–based SARS-CoV-2 vaccines reduced viral load in animals after OC43 infections."
https://www.biorxiv.org/content/10.1101/2021.06.01.446491v1
SARS Coronavirus vaccines protect against different coronaviruses
Tanushree Dangi, Nicole Palacio, Sarah Sanchez, Jacob Class, Lavanya Visvabharathy, Thomas Ciucci, Igor Koralnik, Justin Richner, Pablo Penaloza-MacMaster
https://www.the-scientist.com/news-opinion/the-quest-for-a-universal-coronavirus-vaccine-68934
"The ultimate universal vaccine would protect against all coronaviruses, but the genetic diversity that exists among the four groups makes such a goal very difficult to achieve. Instead, most research groups have zoomed in on the beta coronaviruses—and, more specifically, a subgroup known as sarbecoviruses that includes SARS-CoV-1 and SARS-CoV-2, which are more genetically similar to one another than to MERS-CoV, OC43, or HKU1. Kevin Saunders, a vaccine researcher at the Duke Human Vaccine Institute in North Carolina, says that he sees the universal Coronavirus vaccine efforts as going forward in two phases: first focusing on finding a vaccine for sarbecoviruses, then broadening to MERS-like beta coronaviruses.
It may be possible to one day generate a truly universal Coronavirus vaccine. But before that happens, “a lot of research has to be done to figure out how far you can push this kind of cross-reactive immune recognition,” says Pamela Björkman, a structural biologist at Caltech."
Here is a paper by Kevin Saunders and his colleagues.
https://www.nature.com/articles/s41586-021-03594-0
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
Saunders, K.O., Lee, E., Parks, R. et al.
Nature 594, 553–559 (2021).
https://jamanetwork.com/journals/jama/fullarticle/2781521
"Zeichner and Meng synthesized VFPs for SARS-CoV-2 and porcine epidemic diarrhea virus (PEDV)—a Coronavirus that sickens pigs
...
Unexpectedly, their SARS-CoV-2 vaccine also protected pigs against severe PEDV, suggesting the VFP could be a target for a broadly protective Coronavirus vaccine, Zeichner, Meng, and their coauthors concluded."
Here is the paper by Zeichner, Meng and colleagues
https://www.pnas.org/content/118/18/e2025622118
Killed whole-genome reduced-bacteria surface-expressed Coronavirus fusion peptide vaccines protect against disease in a porcine model.
Maeda et al
Proceedings of the National Academy of Sciences May 2021, 118 (18) e2025622118