COVID Cross Reactive Covid 19 Immunity From Exposure to Endemic Coronaviruses

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The discussion centers on the hypothesis that cross-reactive immunity from endemic coronaviruses may contribute to the mild nature of many COVID-19 cases. Researchers are investigating the impact of pre-existing T-cell responses on SARS-CoV-2 infections, noting that while such responses exist, their protective significance remains unclear. Studies indicate that individuals with recent infections from endemic coronaviruses may experience less severe COVID-19 symptoms. Concerns about the accuracy of seroprevalence estimates, particularly in India and Brazil, suggest that previous infection rates may have been overestimated, complicating the understanding of immunity and reinfection dynamics. Overall, the relationship between cross-reactive immunity and COVID-19 severity warrants further investigation.
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https://www.science.org/doi/10.1126/science.abh1823 A recent HCoV (the collective common endemic coronaviruses) is associated with less severe covid-19.
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