Diabetic Neuropathy: Pathophysiology & Statistics

[mktsgm]

What is the pathophysiological basis for development of neuropathy in diabetes. Or is it just statistics that we find neuropathy in many diabetic patients'.

 

[Dr. Courtney]

https://www.google.com/webhp?source...sis for development of neuropathy in diabetes

 

[mktsgm]

Thanks for your reply. I too have searched Google and got nothing better. Most of the articles return 'Polyol Pathway' as the probable cause for neuropathy due to diabetes. But mostly they are skeptical of it. Wikipedia on "Polyol Pathway" states, ... "It has not been conclusively determined that activating the polyol pathway damages microvasculature"...

Why modern science is unable to produce a credible theory for developing neuropathy due to diabetes?

 

[jim mcnamara]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007052/

Oxidative stress on the neuronal components, in simple terms. The biochemical pathways involved are discussed/referenced in the paper.