Diagonalization of the metric matrix (g_{uv}) in general relativity is possible locally through a proper choice of coordinates, but not globally due to the non-flat nature of spacetime. While some metrics, like the Schwarzschild metric, are already diagonal, the Kerr metric presents challenges. The process of diagonalization can be achieved using methods such as Sylvester's Law of Inertia, but the specific components of the matrix must be known. The introduction of tetrads (4-bein) allows for a trivial metric in tangent space, eliminating the need for complex numbers. Overall, while diagonalization is feasible, its practical implications in general relativity require careful consideration.