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Mitchtwitchita
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Does anybody know where aspirin becomes active, the stomach or the intestines? Based on a test I performed, I would conclude that it is the stomach. However, the results of said test weren't very conclusive.
Mitchtwitchita said:Does anybody know where aspirin becomes active, the stomach or the intestines? Based on a test I performed, I would conclude that it is the stomach. However, the results of said test weren't very conclusive.
Mitchtwitchita said:Thanks Gravenewworld! I had a hunch it was the intestines even though the test led me to believe otherwise.
http://www.rxmed.com/b.main/b2.phar...phs/CPS- (General Monographs- A)/ASPIRIN.htmlWhen ASA is taken orally, it is rapidly absorbed from the stomach and proximal small intestine. The gastric mucosa is permeable to the non-ionized form of ASA, which passes through the stomach wall by a passive diffusion process.
Optimum absorption of salicylate in the human stomach occurs in the pH range of 2.15 to 4.10. Absorption in the small intestine occurs at a significantly faster rate than in the stomach. After an oral dose of 650 mg Aspirin, the plasma acetylsalicylate concentration in man usually reaches a level between 0.6 and 1.0 mg% in 20 minutes after ingestion and drops to 0.2 mg% within an hour. Within the same period of time, half or more of the ingested dose is hydrolyzed to salicylic acid by esterases in the gastrointestinal mucosa and the liver, the total plasma salicylate concentration reaching a peak between 1 or 2 hours after ingestion, averaging between 3 and 7 mg%. Many factors influence the speed of absorption of ASA in a particular individual at a given time; tablet disintegration, solubility, particle size, gastric emptying time, psychological state, physical condition, nature and quantity of gastric contents, etc., all affect absorption.
Distribution of salicylate throughout most body fluids and tissues proceeds at a rapid rate after absorption. Aside from the plasma itself, fluids which have been found to contain substantial amounts of salicylate after oral ingestion include spinal, peritoneal and synovial fluids, saliva and milk. Tissues containing high concentrations of the drug are the kidney, liver, heart and lungs. Concentrations in the brain are usually low, and are minimal in feces, bile and sweat.
The drug readily crosses the placental barrier. At clinical concentrations, from 50% to 90% of the salicylate is bound to plasma proteins especially albumin, while ASA itself is bound to only a very limited extent. However, ASA has the capacity of acetylating various proteins, hormones, DNA, platelets and hemoglobin, which at least partly explains its wide-ranging pharmacological actions.
The liver appears to be the principal site for salicylate metabolism, although other tissues may also be involved. The three chief metabolic products of salicylic acid are salicyluric acid, the ether or phenolic glucuronide and the ester or acyl glucuronide. A small fraction is also converted to gentisic acid and other hydroxybenzoic acids. The half-life of Aspirin in the circulation is from 13 to 19 minutes so that the blood level drops quickly after absorption is complete. However, the half-life of the salicylate ranges between 3.5 and 4.5 hours, which means that 50% of the ingested dose leaves the circulation within that time.
ghost02 said:How did you perform this test?
Aspirin is a common pain reliever and anti-inflammatory medication. It works by inhibiting the production of prostaglandins, which are chemicals that contribute to pain and inflammation in the body.
Aspirin is absorbed in the small intestine through the process of passive diffusion. It is then broken down into its active form, salicylic acid, which is able to enter the bloodstream and reach targeted areas of the body.
Aspirin becomes active in the bloodstream, as it is broken down into salicylic acid. It then travels throughout the body and exerts its effects on pain and inflammation.
The effects of aspirin can usually be felt within 30 minutes of ingestion. However, it may take up to 1-2 hours for the full effects to be felt. The duration of action can last for 4-6 hours.
Yes, factors such as the presence of food in the stomach, pH levels, and other medications can affect the absorption and activation of aspirin in the body. It is important to follow dosage instructions and consult with a healthcare professional before taking aspirin with other medications.