Genes and protein they code size relation?

Click For Summary
SUMMARY

The relationship between gene size and the size of the protein it codes for is generally affirmative, with specific considerations. The gene must refer to the coding sequence or the total length of exons, as eukaryotic genes contain noncoding introns that can affect this relationship. Additionally, proteins are often composed of multiple polypeptides, and post-translational modifications such as cleavage by peptidases can further complicate the size correlation. Despite these factors, the basic premise holds true in many cases.

PREREQUISITES
  • Understanding of eukaryotic gene structure, including exons and introns
  • Knowledge of polypeptide assembly and protein structure
  • Familiarity with post-translational modifications in proteins
  • Basic concepts of molecular biology and genetics
NEXT STEPS
  • Research eukaryotic gene structure and the role of introns
  • Study polypeptide assembly and the concept of protein complexes
  • Explore post-translational modifications and their effects on protein function
  • Investigate the relationship between gene expression and protein synthesis
USEFUL FOR

Molecular biologists, geneticists, and anyone interested in the relationship between gene size and protein structure will benefit from this discussion.

icakeov
Messages
379
Reaction score
27
If the gene is smaller, is the protein that it codes for smaller too?
Vice versa?
 
Biology news on Phys.org
I guess that is true, and even accurately true, with certain caveats.

One would be that by 'gene' here you'd have to mean coding sequence or the total length of exons. That is in eukaryotes the DNA coding sequence that represents the sequence of the protein product) can be interrupted by nonencoding sequences called introns so if you counted these the relation would be a lot more variable.

Another caveat would be that by protein you have to mean polypeptide. Functional proteins on more often than not are assemblages of for example two, four or six etc. Identical or nonidentical polypeptides.

Then sometimes there is post-translational processing - cleavage by peptidases of the initial polypeptide product.

And no doubt other complications.

But except for these overlaying factors, in the simplest cases the answer to your question is yes.
 
  • Like
Likes   Reactions: icakeov
Great, thanks epenguin, yes, I was wondering whether in general cases it checks out to be related!
 

Similar threads

Replies
12
Views
5K
  • · Replies 4 ·
Replies
4
Views
2K
  • · Replies 11 ·
Replies
11
Views
2K
  • · Replies 3 ·
Replies
3
Views
2K
  • · Replies 1 ·
Replies
1
Views
2K
  • · Replies 10 ·
Replies
10
Views
2K
  • · Replies 6 ·
Replies
6
Views
2K
Replies
5
Views
2K
Replies
4
Views
3K
  • · Replies 2 ·
Replies
2
Views
1K