Rongeet Banerjee
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How exactly do Stem Cells help in Drug trials ?Or do they really
How do Stem Cells help in Drug trials?
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What research have you done on this? What have you found out?Rongeet Banerjee said:
Rongeet Banerjee
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Actually I am an Undergraduate Medical student in my 1st yr.I found the following page in my Embryology Textbook . But
couldn't understand the last line.
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So you decided to post it sideways to make it easy for us to read?Rongeet Banerjee said:
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Guessing that stem cells are used in vitro for testing of drugs.
The stem cells would have the testing species specificity of the species from which they were derived.
So, mouse stem cells; good for testing drugs that might be used on mice.
The cells would have to have the proper receptors (or whatever is appropriate for testing).
Alternatively, the stem cells might be used to situations where they could be dependably differentiated into particular non-stem cells, which would have the right receptors or physiology for the drug test.
There could well be cases where stem cells would not be appropriate for testing particular drugs, for example not having the physiology typical of some body part.
The stem cells would have the testing species specificity of the species from which they were derived.
So, mouse stem cells; good for testing drugs that might be used on mice.
The cells would have to have the proper receptors (or whatever is appropriate for testing).
Alternatively, the stem cells might be used to situations where they could be dependably differentiated into particular non-stem cells, which would have the right receptors or physiology for the drug test.
There could well be cases where stem cells would not be appropriate for testing particular drugs, for example not having the physiology typical of some body part.
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Here's something you can try some day:
I typed into the google search bar "How do Stem Cells help in Drug trials?"
Then I got lots of links to good answers.
For example, The first page of the first link had this:
"How can pluripotent stem cells speed drug development?
Stem cells are expected to dramatically improve the ability of drug companies to screen new drugs for side effects much earlier in the development process— significantly lowering costs and shortening the time it takes to develop a new drug. Right now, all drugs go through extensive animal trials before they are ever given to people. This can take years and cost millions of dollars. And even if the drugs appear perfectly safe in animals—there is no guarantee that the same will be true for humans
The ideal solution to the problem of drug side effects would be to test the drugs on human cells before the drugs enter human clinical trials. The most common drug side effects are on the liver, kidney and heart. For that reason, those are the tissues people are trying to create from pluripotent stem cells to use for screening drug toxicity.
With toxicity screening, drug companies would have banks of stem cells from a wide variety of genetic backgrounds. They could then test how heart, liver, or kidney cells created from those stem cells react to a drug—thus weeding out those drug candidates that lead to toxicity in human cells.
This work also could reveal groups of people with similar genetic backgrounds that collectively do or don’t respond well to a given drug. This type of personalized medicine would allow drug companies to develop drugs that are safe and effective in targeted groups of people."
(https://www.cirm.ca.gov/patients/ac...ng, drug companies,to toxicity in human cells.)
I typed into the google search bar "How do Stem Cells help in Drug trials?"
Then I got lots of links to good answers.
For example, The first page of the first link had this:
"How can pluripotent stem cells speed drug development?
Stem cells are expected to dramatically improve the ability of drug companies to screen new drugs for side effects much earlier in the development process— significantly lowering costs and shortening the time it takes to develop a new drug. Right now, all drugs go through extensive animal trials before they are ever given to people. This can take years and cost millions of dollars. And even if the drugs appear perfectly safe in animals—there is no guarantee that the same will be true for humans
The ideal solution to the problem of drug side effects would be to test the drugs on human cells before the drugs enter human clinical trials. The most common drug side effects are on the liver, kidney and heart. For that reason, those are the tissues people are trying to create from pluripotent stem cells to use for screening drug toxicity.
With toxicity screening, drug companies would have banks of stem cells from a wide variety of genetic backgrounds. They could then test how heart, liver, or kidney cells created from those stem cells react to a drug—thus weeding out those drug candidates that lead to toxicity in human cells.
This work also could reveal groups of people with similar genetic backgrounds that collectively do or don’t respond well to a given drug. This type of personalized medicine would allow drug companies to develop drugs that are safe and effective in targeted groups of people."
(https://www.cirm.ca.gov/patients/ac...ng, drug companies,to toxicity in human cells.)
Rongeet Banerjee
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Sorryphinds said:
Rongeet Banerjee
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Thank You Sirberkeman said: