How to titrate compound contains butanoic and phosphoric aci

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Discussion Overview

The discussion revolves around the titration of a compound containing both butanoic acid and phosphoric acid. Participants explore the methodology for titration, the expected outcomes in terms of peaks, and how to calculate the assay of the compound.

Discussion Character

  • Technical explanation, Debate/contested, Experimental/applied

Main Points Raised

  • One participant inquires about the titration process for a compound containing both butanoic and phosphoric acid, specifically asking about the expected peak when titrated with NaOH and how to calculate the assay.
  • Another participant emphasizes that titration calculations depend on stoichiometry and the pKa values of the functional groups involved, suggesting that without this information, predicting neutralization stoichiometry is not feasible.
  • A participant expresses a desire to perform the assay using 0.1 N NaOH and questions how many endpoints to expect during the titration.
  • There is a reiteration of the importance of knowing the pKa values to determine the number of expected endpoints in the titration process.

Areas of Agreement / Disagreement

Participants appear to agree on the necessity of knowing the pKa values for accurate predictions regarding the titration process. However, there is no consensus on the expected outcomes or the specifics of the titration methodology.

Contextual Notes

The discussion highlights limitations related to the unknown pKa values of the functional groups, which affects the ability to predict neutralization stoichiometry and the number of expected endpoints.

Rahulmkotkar
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How to titrate compound contains both function group butanoic and phosphoric acid? How much peak we expect if we titrate it with NaOH? How to calculate assay of that compound.
 
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All titrations and all titration calculations are based on stoichiometry. Not knowing pKa of involved groups (you wrote "compound containing functional groups", so I assume it is not a mixture) it is impossible to predict neutralization stoichiometry.

No idea what peak you are talking about - no peaks in titration (unless you refer to some method of endpoint detection).
 
Thanks Borek, I want to do assay by titration of one of the pharmaceutical compound contains both these function group ( phosporic acid and butanoic acid). Can i go for titration with 0.1 N NaOH, and how many end point i should expect?
 
Rahulmkotkar said:
and how many end point i should expect?

I already told you:

Borek said:
Not knowing pKa of involved groups (...) it is impossible to predict neutralization stoichiometry.
 

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