If I'm losing muscle mass , are some of my muscle cells actually disappearing?

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Discussion Overview

The discussion revolves around the relationship between muscle mass loss and the potential disappearance of muscle cells, particularly in the context of weight loss and exercise. Participants explore the mechanisms of muscle and fat cell dynamics, including conditions that may lead to muscle cell loss and the role of dietary factors.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation

Main Points Raised

  • One participant questions whether muscle cells actually disappear when losing muscle mass, expressing concern about the effects of reduced weight training.
  • Another participant asserts that fat cells do not disappear but rather grow in size, prompting questions about the conditions under which muscle cells may be lost.
  • A later reply clarifies that muscle cells are relatively static and do not undergo significant cell division, suggesting that muscle atrophy occurs through the breakdown of myofibers rather than cell death.
  • Concerns are raised about the risk of muscle loss due to carnitine deficiency in individuals who exercise heavily and consume little meat, with a request for clarification on the implications of this deficiency.
  • Participants discuss whether fat cells are utilized for energy before muscle cells and the conditions under which muscle cells might be consumed for energy.

Areas of Agreement / Disagreement

There is no consensus on whether muscle cells can disappear or how they are affected by weight loss and exercise. Multiple competing views exist regarding the dynamics of muscle and fat cells, and the discussion remains unresolved.

Contextual Notes

Participants express uncertainty about the specific conditions that lead to muscle cell loss and the metabolic roles of carnitine, indicating a need for further exploration of these topics.

pa5tabear
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If I'm "losing muscle mass", are some of my muscle cells actually disappearing?

I've been running a lot lately and losing weight. Mostly getting leaner, but recently I've started to worry about losing muscle mass. I used to lift weights a lot, but I haven't done that in a few months. If I keep up my current routine, will the muscle cells shrink? Will they be consumed or disappear, so that there are then fewer muscle cells?
 
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yes unfortunately, the converse is true with fat cells
 


mazinse said:
yes unfortunately, the converse is true with fat cells

Are you saying that fat cells never go away? Are new ones formed when you get fatter?

Under what sort of conditions do muscle cells go away? And are they directly consumed by the body for energy? How would this happen?

If there are fat cells present, will the fat cells always be "utilized" for energy before the muslce cells?
 


pa5tabear said:
I've been running a lot lately and losing weight. Mostly getting leaner, but recently I've started to worry about losing muscle mass. I used to lift weights a lot, but I haven't done that in a few months. If I keep up my current routine, will the muscle cells shrink? Will they be consumed or disappear, so that there are then fewer muscle cells?

mazinse said:
yes unfortunately, the converse is true with fat cells

That is incorrect.

Skeletal muscle exists as a syncytium. When you loose muscle mass from under-use of muscle or something like starvation, your body breaks down the myofibers (composed of protein). Muscle cells are relatively static throughout life and do little in the way of cell divisions.

Unless a very pathological process is happening your muscle cells shouldn't be dying off (necrosis).

More info if you are interested; muscle atrophy
 


pa5tabear said:
Are you saying that fat cells never go away? Are new ones formed when you get fatter?

Under what sort of conditions do muscle cells go away? And are they directly consumed by the body for energy? How would this happen?

If there are fat cells present, will the fat cells always be "utilized" for energy before the muslce cells?

Fat too for the most part is relatively static. In most people, the amount of fat cells you have starting adulthood is what you keep throughout most of your adult life. These fat cells grow by hypertrophy not hyperplasia under normal circumstances and for most people. There are exceptions to this in things like inherited problems leading to obesity. But for the average American, packing on the pounds means expanding the volume of the fat cells you already have.
 


People who exercise a lot, while consuming little meat, and lose significant weight, are sometimes at risk of muscle loss due to deficiency in carnitine in the body. If you fit that description, seek qualified medical or nutritional advice.
 


Jim Pivonka said:
People who exercise a lot, while consuming little meat, and lose significant weight, are sometimes at risk of muscle loss due to deficiency in carnitine in the body. If you fit that description, seek qualified medical or nutritional advice.

Is this true? I just scanned the wikipedia on carnitine and it looks like carnitine assists in metabolism of fats. Yes, if you're consuming little meat, then you won't be getting much carnitine. Does this mean muscles will be utilized for energy more than they would if carnitine were more bioavailable in the body?
 

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