Yes, there are lots of examples of that sort of design. Loop-backs, interlocks, different shield terminations and such. But those are asymmetrical circuits not directional current flow through copper. In good designs you can't plug those in backwards, the connectors won't allow it. You can be pretty sure that arrows on the cable jacket will be ignore much of the time.The only truly directional cables I've seen are some guitar signal cables, they have a connector at the guitar end that shorts the cable so that you don't get that awful buzz/crash when you plug it in. They have directional arrows on them but it isn't for signal flow.