Dismiss Notice
Join Physics Forums Today!
The friendliest, high quality science and math community on the planet! Everyone who loves science is here!

Is it possible to synthesize adrenaline in the lab?

  1. Aug 15, 2007 #1
    Is it possible to synthesize adrenaline in the lab?
  2. jcsd
  3. Aug 15, 2007 #2
    Yes it shouldn't be taht hard.
  4. Aug 15, 2007 #3
    our body does it all the time :rolleyes:
  5. Aug 16, 2007 #4
    I did a search for possible starting materials and looked at the cost vs. how many steps for a possible synthesis and you could do it this way:

    Buy 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone, 97% (500 g, $283 Alpha Aesar)

    Do a substitution of the chlorine with methyl amine (use a large excess of methyl amine).

    Reduce the carbonyl stereoselectively using 1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole, tetrahydro-1-methyl-3,3-diphenyl-, (S)- with Borane Dimethyl sulfide complex in THF.

    I've done the reduction before, it works pretty well (>75% yield)

    That should give you adrenaline.
  6. Aug 18, 2007 #5
    that doesn't means it's easy, in fact it's generally the opposite. enzymes regularly do chemistry that we cant dream of doing in the lab.
  7. Sep 7, 2007 #6
    Point taken.
  8. Sep 11, 2007 #7


    User Avatar
    Science Advisor
    Gold Member

    Apparently, it was first synthesised in the lab in 1904 by Freidrich Stolz...
  9. Oct 4, 2007 #8
    Hint: Meth is 1 atom away from adrenaline..
Share this great discussion with others via Reddit, Google+, Twitter, or Facebook