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Is it possible to synthesize adrenaline in the lab?

  1. Aug 15, 2007 #1
    Is it possible to synthesize adrenaline in the lab?
     
  2. jcsd
  3. Aug 15, 2007 #2
    Yes it shouldn't be taht hard.
     
  4. Aug 15, 2007 #3
    our body does it all the time :rolleyes:
     
  5. Aug 16, 2007 #4
    I did a search for possible starting materials and looked at the cost vs. how many steps for a possible synthesis and you could do it this way:

    Buy 2-Chloro-1-(3,4-dihydroxyphenyl)ethanone, 97% (500 g, $283 Alpha Aesar)

    Do a substitution of the chlorine with methyl amine (use a large excess of methyl amine).


    Reduce the carbonyl stereoselectively using 1H,3H-Pyrrolo[1,2-c][1,3,2]oxazaborole, tetrahydro-1-methyl-3,3-diphenyl-, (S)- with Borane Dimethyl sulfide complex in THF.

    I've done the reduction before, it works pretty well (>75% yield)

    That should give you adrenaline.
     
  6. Aug 18, 2007 #5
    that doesn't means it's easy, in fact it's generally the opposite. enzymes regularly do chemistry that we cant dream of doing in the lab.
     
  7. Sep 7, 2007 #6
    Point taken.
     
  8. Sep 11, 2007 #7

    brewnog

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    Apparently, it was first synthesised in the lab in 1904 by Freidrich Stolz...
     
  9. Oct 4, 2007 #8
    Hint: Meth is 1 atom away from adrenaline..
     
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