Mathematical process for protein folding

AI Thread Summary
The discussion centers on the challenges of designing a specific protein to inhibit DNA transcription, particularly through the interaction with CDK and cyclins. The original poster seeks guidance on how to predict and create such a protein, expressing concerns about the lack of accessible resources and the need for advanced computational tools. Participants highlight that protein folding is a complex problem, often requiring substantial computational power due to the intricate interactions of proteins with their environment. There is mention of the potential for quantum computing and artificial intelligence, like AlphaFold 2, to aid in solving these challenges. The conversation suggests that while mathematical approaches to protein folding exist, they may not be feasible without computational assistance.
Hopper_18
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TL;DR Summary
Trying to determine if there is a mathematical process for protein folding that can be done without a computer to create a new protein that’s function would be a combination of multiple real life protein.
Hello, I am currently working on an idea for a possible future masters or PhD in cellular biology, however my idea is currently just a passion project. For it to work, I would need to learn how to predict and make a specific protein to do a specific function, in this instance I need to use it to inhibit the transcription of certain DNA region by finding to different CDK and cycling.

I have been some research into this but have found no website or otherwise study describing how one could go about doing this, without substantial expertise and a super computer. Even then it was comparing it to other already recognized proteins in which the function would be similar.

I was wondering if anyone could explain how one might create a protein to do a specific function in which the desired function would be a combination of multiple proteins in real life? Also is there a way to determine this protein folding mathematically or otherwise without a computer, or is purely computer based?

Thank you for any information that you can provide.
 
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From what little I know of the subject, it seems to be a combinatorial problem.
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Yup, I asked Google:
https://www.google.com/search?&q=why+is+protein+folding+hard

This being the first response:
...the protein interacts with surrounding water when folding. So you have more like 30k atoms to simulate

Unless your IQ is in the 5 or 6 digit range and have an eidetic memory, get access to a LARGE computer.

Have Fun!
Tom
 
Tom.G said:
From what little I know of the subject, it seems to be a combinatorial problem.
.
.
.
Yup, I asked Google:
https://www.google.com/search?&q=why+is+protein+folding+hard

This being the first response:
...the protein interacts with surrounding water when folding. So you have more like 30k atoms to simulate

Unless your IQ is in the 5 or 6 digit range and have an eidetic memory, get access to a LARGE computer.

Have Fun!
Tom
Some threads this year on the subject including the Alpha 2 program. I will dig out.
 
Hopper_18 said:
TL;DR Summary: Trying to determine if there is a mathematical process for protein folding that can be done without a computer to create a new protein that’s function would be a combination of multiple real life protein.

Hello, I am currently working on an idea for a possible future masters or PhD in cellular biology, however my idea is currently just a passion project. For it to work, I would need to learn how to predict and make a specific protein to do a specific function, in this instance I need to use it to inhibit the transcription of certain DNA region by finding to different CDK and cycling. I have been some research into this but have found no website or otherwise study describing how one could go about doing this, without substantial expertise and a super computer. Even then it was comparing it to other already recognized proteins in which the function would be similar. I was wondering if anyone could explain how one might create a protein to do a specific function in which the desired function would be a combination of multiple proteins in real life? Also is there a way to determine this protein folding mathematically or otherwise without a computer, or is purely computer based? Thank you for any information that you can provide.
I believe that protein folding is a very hard problem. The hope is that it can be solved by quantum computers, or perhaps artificial intelligence will be good enough.
 
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