Welcome to physicsforums lee phong!
I don't think there is a real disadvantage to doing two runs with different sources and combining the results. This also has the advantage that some mistakes are easier to spot and if you want to change the source strength of one relative to the other you don't need to rerun the simulation.
If you wrote, or fully understand the F-18 sdef, then you understand everything you need to extend this to a second source. The file uses dependent variables to emit photons, with one probability distribution (d12) and electrons with another (d13), the iodine is a photon source you can rename this to make d14 and add those lines. Then extending SI11 to be L P E P, extend SP11 for the strength. And extend DS10 to DS10 S 12 13 14
Does that make sense? If the iodine was an electron source too it might be SI11 L P E P E, and then all dependent variables of PAR would need 4 entries.
With three entries, you need a dependent variable for POS. DS15 L ax ay az bx by bz cx cy cz
Where a is the position for the F-18 photons, b is the position of the F-18 electrons (the same) and c is the location for the I-131 photon source. In sdef pos becomes pos=fpar=d15 from the default 0 0 0.
You may need another dependent variable for CEL, since the sources seem to be in different cells but it will work exactly the same way.
If anything isn't clear, just ask.