Microarrays -- why do they have low reproducibility

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Microarrays exhibit low reproducibility compared to SAGE primarily because they struggle to detect unknown genes, which SAGE can identify. This limitation affects the consistency of results across different experiments. While SAGE provides more comprehensive gene expression data, it operates at a slower pace than microarrays. The trade-off between speed and accuracy is a significant factor in choosing between these two technologies. Overall, the inherent differences in detection capabilities contribute to the reproducibility challenges faced by microarrays.
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Why do microarrays have low reproducibility compared to SAGE?
 
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