Is CCSVI the Key to Treating Multiple Sclerosis?

  • Context: Medical 
  • Thread starter Thread starter algis.j
  • Start date Start date
  • Tags Tags
    Multiple
Click For Summary

Discussion Overview

The discussion revolves around the potential role of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in the treatment and understanding of Multiple Sclerosis (MS). Participants explore various hypotheses regarding the mechanisms of CCSVI, the use of antibiotics and iron chelation, and the implications for MS treatment.

Discussion Character

  • Exploratory
  • Debate/contested
  • Technical explanation
  • Conceptual clarification

Main Points Raised

  • Some participants highlight the emerging interest in CCSVI as a potential treatment for MS, referencing controlled studies based on Dr. Zamboni's protocol.
  • There is speculation about the use of iron chelators, including common antibiotics like tetracycline, to reduce inflammation associated with MS.
  • One participant questions the ability of antibiotics to chelate iron, while another later provides evidence suggesting that certain tetracyclines do possess iron-chelating activity.
  • Concerns are raised about the complexity of MS, with some arguing that inflammation may be a significant factor, and that various treatments may work differently for individuals.
  • Participants discuss the possibility of using high magnetic fields to remove iron from the brain, although one participant expresses skepticism about this approach.
  • There is a mention of the historical focus on autoimmunity in MS research, with some suggesting that the exploration of blood flow issues has not yielded significant results in the past.

Areas of Agreement / Disagreement

Participants express a range of views on the role of CCSVI and the mechanisms involved in MS. There is no consensus on the effectiveness of proposed treatments or the validity of the underlying theories, indicating ongoing debate and uncertainty.

Contextual Notes

Some claims about the efficacy of antibiotics and their mechanisms remain unresolved, and the discussion includes various assumptions about the relationship between iron, inflammation, and MS pathology.

algis.j
Messages
28
Reaction score
0
A new approach to Multiple Sclerosis cause/treatment. Chronic CerebroSpinal Venous Insufficiency. It is presently making a boom in the MS society.

http://csvi-ms.net/en
http://news.bbc.co.uk/2/hi/health/8374980.stm
http://www.theglobeandmail.com/news/national/ms-group-calls-for-research-into-potentially-paradigm-shifting-theory/article1374954/

Would that exam require specially-trained radiologists? It seems to be a special procedure and up to now only few hospital offer the service.
Canadian MS Society will start a controlled study based on the Dr.Zamboni's protocol.

Cheers all;

Algis
 
Last edited by a moderator:
Biology news on Phys.org
Very exciting developments! WOW!

http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20091120/W5_liberation_091121/20091121?s_name=W5

I wonder if iron chelators can be used to decrease the inflammation.

Anybody have any information regarding the ability of common antibiotics to chelate iron? Common antibiotics like tetracycline?
 
Last edited by a moderator:
Thanks for posting this, Algis. I read the links and sent one to my brother-in-law who has MS. He also used to be an ER doc. Currently he's taking a daily injection of something that seems to have pretty much halted the progress of the disease.
 
@Chemisttree: I want to correct myself - I found this while doing my researches:

Three tetracyclines (tetracycline, doxycycline, and minocycline) were found to possesses iron-chelating activity in a colorimetric siderophore assay.
Determination of MICs indicated that the activity of doxycycline against the periodontopathogen Actinobacillus Actinomycetemcomitans was only slightly influenced by the presence of an excess of iron that likely saturates the antibiotic. On the other hand, the MICs of doxycycline and minocycline were significantly lower for A. actinomycetemcomitans cultivated under iron-poor conditions than under iron-rich conditions.

PMID: 10681353

@Zoobyshoe: you're welcome.
 
algis.j said:
@chemisttree: I want to correct myself - I found this while doing my researches:...

I asked because antibiotics http://www.news-medical.net/news/2007/12/11/33410.aspx" and treats it with antibiotics. I wonder if the action of the antibiotic could simply be due to iron chelation rather than the elimination of extremely low levels of Bartonella.

Of course whatever antibiotic chelating action would presuppose it could cross the blood brain barrier.
 
Last edited by a moderator:
Doxycycline and minocycline are sometimes used with MS patients. But there are probably other iron chelator agents out there; Phytic Acid?
 
i dunno, too much of this sounds like you're simply dealing with inflammation. so, a lot of things seem to help a lot of different people with MS because there are a lot of ways to modulate inflammatory response. anyone tried infecting them with worms, yet?

oh, and a little searching seemed to indicate that inflammation causes blood Fe to go down, but that it ends up in tissues like the liver. and brain.
 
I wish it would be that simple :D
 
  • #10
yeah, i know it's not, but i think the mainstream is still focused on autoimmunity. and i saw something saying they'd been down this bloodflow road before and it went nowhere.
 
  • #11
It is not because they are a lot to be wrong that they are right...

Thank you all :)
 
  • #12
chemisttree said:
I asked because antibiotics http://www.news-medical.net/news/2007/12/11/33410.aspx" and treats it with antibiotics. I wonder if the action of the antibiotic could simply be due to iron chelation rather than the elimination of extremely low levels of Bartonella.

Of course whatever antibiotic chelating action would presuppose it could cross the blood brain barrier.

Is there any other way? Is it possible to pull out and remove the iron with high magnetic field? Any new idea?
 
Last edited by a moderator:
  • #13
Doxycycline has worked for some; it is an antibiotic ~and~ iron chelator... So tough call...

The idea behind CCSvI is:
blood slowing because narrowing of the veins.
Blood percolate because of endothelial permability;
iron of the blood bind with myelin;
immune system eat iron - and the bounded myelin...

It is reasonable. It puzzle medical corps since so long it becomes desperate...
 
  • #14
Sorry: I do not think magnetic field could separate molecules in the brain... Fe is binding with fat; which myelin is rich of.
 

Similar threads

Medical Universal Virus? - mononucleosis, chronic fatigue, multiple sclerosis....
  • · Replies 3 ·
Replies
3
Views
2K
Medical Marijuana May Help Multiple Sclerosis Patients?
  • · Replies 5 ·
Replies
5
Views
4K
Medical What is the mechanism of using EMDR for treating PTSD?
  • · Replies 2 ·
Replies
2
Views
2K
Medical Fecal Transplants to Cure Disease?
  • · Replies 4 ·
Replies
4
Views
5K