Need help with peak deconvolution

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    Deconvolution Peak
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Discussion Overview

The discussion revolves around the topic of peak deconvolution, specifically seeking guidance on understanding the concept and finding suitable software for its application. Participants explore foundational knowledge related to Fourier transforms and convolution, as well as practical software solutions.

Discussion Character

  • Exploratory
  • Technical explanation
  • Homework-related

Main Points Raised

  • One participant expresses a lack of understanding of peak deconvolution and seeks deeper insights.
  • Another participant asks about familiarity with Fourier transforms and the convolution theorem to tailor assistance.
  • A participant mentions they are not familiar with Fourier transforms and inquires about the software "Igor" for peak deconvolution.
  • One participant requests clarification on what specifically needs to be deconvolved.
  • A later reply details that the data involves a curve of intensity versus time, which combines the instrument response factor (IRF) and fluorescence intensity, and seeks suggestions for deconvolution methods.

Areas of Agreement / Disagreement

The discussion does not present a consensus, as participants are at different levels of understanding and familiarity with the necessary concepts and tools. Multiple viewpoints regarding the approach to peak deconvolution and the software options remain open.

Contextual Notes

Participants have not established a common understanding of foundational concepts like Fourier transforms, which may affect the depth of assistance provided. The specific relationship between the IRF and fluorescence intensity is not fully explored, leaving some assumptions unaddressed.

Sheng2016
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I am new to peak deconvolution, I try to find information about this on the internet but just get a brief understanding of it. Can anyone provide me some suggestions or information about having a deeper understanding of this thing?
 
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Hello Sheng, :welcome:

You need to help us to provide assistance at the right level. Are you familiar with Fourier transforms ? The convolution theorem ? If not, google and pick the style of presentation you like best
 
BvU said:
Hello Sheng, :welcome:

You need to help us to provide assistance at the right level. Are you familiar with Fourier transforms ? The convolution theorem ? If not, google and pick the style of presentation you like best

Hi BvU,

I am not quite familiar with the Fourier transforms, I am trying to find some software that can help me with peak deconvolution. Do you know the software called "Ignor"? I'm trying to find if this can help me or not. Thanks!
 
What in particular are you trying to deconvolve?
 
gleem said:
What in particular are you trying to deconvolve?

I got data from experiment,it is a curve about intensity and time, and it is a combination of the IRF (instrument response factor) and the fluorescence intensity that I want to separate. Their relationship is
fit-1.png

whereas L is the IRF and I is the fluorescence intensity, N is the convolution. I am learning Igor now and try to find if it can help me to deconvolute it. Do you have any suggestions? Thanks!
 

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