Nick Lanes on Sean Carroll's podcast

  • Thread starter Thread starter BillTre
  • Start date Start date
AI Thread Summary
Sean Carroll's podcast features Nick Lane discussing his metabolism-first approach to the origin of life, emphasizing alkaline hydrothermal vents as the likely site of life's emergence. Lane's new book, "Transformer: the deep chemistry of life and death," explores these themes in depth. Recent research highlights the importance of bridging top-down and bottom-up approaches in abiogenesis studies, with references to prominent figures in the field like Russell and Oparin. A notable PNAS paper discusses the origin of ATP synthase and the formation of long-chain fatty acids in thermal vents, which could have contributed to early protocells. Additionally, a study on the RNA world model reveals the significance of replication fidelity in early RNA systems, suggesting that molecular evolution may have started with RNA enzymes capable of accurate replication and variation.
BillTre
Science Advisor
Gold Member
2024 Award
Messages
2,670
Reaction score
11,538
TL;DR Summary
Nick Lanes is a primary proponent of a metabolisms first, alkaline hydrothermal vent approach to the origin of life. He has just published a book on how core metabolism could have preceded the origin of life. He has a new book on this stuff.
Here is one of Sean Carrol's podcasts. He talks with Nick Lane who is one of the most interesting (to me) people publishing on origin of life issues. He takes a strong metabolism first approach to the origin of life and also strongly favors alkaline hydrothermal vents as the site for where life emerged.
He has a new book out: Transformer: the deep chemistry of life and death.
 
Last edited:
  • Like
  • Informative
  • Love
Likes hutchphd, mattt, atyy and 2 others
Biology news on Phys.org
Here is another video I just found by Nick Lane.
This one is nice in that he is only talking about origin of life issues and goes into a lot of detail on how early biochemistry might have worked.
 
  • Like
Likes Laroxe and pinball1970
@BillTre

This was in phys.org last week

https://www.pnas.org/doi/10.1073/pnas.2300687120

I quick flick through the refs and all the usual suspects there including Russell, Lane, Oparin, Wächtershäuser.
There was a debate on YT regarding research on abiogenesis recently (interesting but not for pf )
 
Last edited:
Recent work on the "RNA world" model

https://www.pnas.org/doi/10.1073/pnas.2321592121

From the abstract,

"This study demonstrates the critical importance of replication fidelity for maintaining heritable information in an RNA-based evolving system, such as is thought to have existed during the early history of life on Earth."

https://phys.org/news/2024-03-life-evidence-rna-world.html

from the article

"The study, published in Proceedings of the National Academy of Sciences (PNAS), unveils an RNA enzyme that can make accurate copies of other functional RNA strands, while also allowing new variants of the molecule to emerge over time. These remarkable capabilities suggest the earliest forms of evolution may have occurred on a molecular scale in RNA."
 
  • Like
  • Informative
Likes Astranut and BillTre
Wow, it took them a while to find one that would work.

I thought for some reason PNAS had gone open access. I guess that was wrong on that.
Hammerhead RNA's are between 50 and 150 nucleotides long, but a core of 15 invariant bases and 3 helical stems (not sequence invariant). Other parts would seem to be more variable.
 
  • Informative
Likes pinball1970

Similar threads

Back
Top