I think you need to define your terms a little better. For example, what do you mean by "more waste per used Uranium"? Do you mean the total mass of the discharged fuel, the mass of the fission products, the mass of the actinides, or perhaps the heat load of the waste? As others have pointed out, lower discharge burnups will increase the total amount of mass, but will have decreased fission product inventories. If you know exactly what you are looking for, you can run a depletion calculation and find out the answer. The usual limits on a spent fuel repository are volume and heat load.
Second, how do you define "time required for the spent fuel to be completely safe"? There really isn't such a thing. You can always trip or choke on a piece of metal, so nothing is ever "completely safe". Maybe you mean the amount of time for the radioactivity of the spent fuel to match the radioactivity of natural uranium? Even so, does it matter if one is radioactive for 100,000 years and another one is radioactive for 120,000 years?
If you don't look too closely at the details, energy comes from fission, so the same amount of power generated by a CANDU or a LWR is going to require the same number of fissions, which will produce the same number of actinides and fission products. There may be some slight differences due to the neutron spectrums, but they will be similar numbers.