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Organic chemistry determing nucleophile strength

  1. Oct 29, 2008 #1
    this isn't exactly an specific question but a general one. I know that weak bases make good nucleophiles but how do I determine what bases are the weakest, what is weak enough to be considered a "good nucleophile" I'm a little confused please help thanks a lot!
  2. jcsd
  3. Oct 31, 2008 #2


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    In general the more basic an agent is the more nucleophilic , however there are other factors to consider besides basicity. Your teacher is probably not going to get specific , just know the common bases that are considered weak or strong.
  4. Oct 31, 2008 #3
    To determine base strength you need to look at the pKa value for the molecules conjugate acid (add an H+ to the molecule). If the conjugate acid has a low pKa (strong acid) then the original molecule is a weak base...and high pKa=strong base.
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