For some reason, I can't seem to be able to find this answer easily on the internet. Or it is there and I somehow I can't see the wood for the trees. I know that in transcription (when DNA is read for protein production), "RNA polymerase" is the protein that creates the mRNA by creating the new strand. What is the protein (or proteins) in charge when DNA is being duplicated during interphase, before mitosis happens? (I just found out that there is helicase, DNA polymerase, primase and ligase! So I am guessing DNA polymerase would be the answer, which leaves me with the question below) Furthermore, when would this protein be produced? Is the protein produced when the time comes to double the DNA so it can get to work of duplication, or is the protein floating around and goes into a conformational change to start the DNA duplication process? And a new addendum to this question, I am pretty sure the answer is yes to this, but just want to make sure: does RNA polymerase create the mRNA that then creates the DNA polymerase hormone? And also does RNA polymerase also create itself? I appreciate any feedback!