The RELATIONSHIPS between the tones is interesting - consonance versus dissonance.
Go through the prime numbers:
1) 440*1=440. :- closest relation is itself
2) 440*2=880. :- A, same note one octave higher - very consonant
440/2=220. :- A, same note one octave lower - " "
3) 440*3=1320 :- E, 19 steps up - consonant
440*3/2=660 :- E, 7 steps up - "
440/3=146.67 :- D, 19 steps down - consonant
440/3*2=293.333 :- D, 7 steps down - "
5) 440*5=2200 :- Dflat, 28 steps higher
440*5/4=550 :- Dflat , 4 steps higher
there is more
. . . . and so on and so forth - tending towards dissonance as you progress through the primes
The chromatic scale uses the twelvth root of 2 ( 1.059463094) as has been already expressed in the above posts, and it is interesting to see the difference
Natural E, 7 steps up = 660
Chromatic E, 7 steps up = 659.25