If the speed of light is affected by the nature of our non-inertial reference frame, then there should be an anisotropy in that speed. This is because we know there is a sense of rotation of the earth, both on its own axis, and in its orbit around the sun. Thus, by changing the orientation of the apparatus that we do our experiment with, we should detect a difference in the speed of light.
This type of experiment has been done multiple times, starting with the infamous MM experiment, and until the present time. In fact, the Standard Model extension (SME) for possible Lorentz violation, and the Robertson-Mansouri-Sexl theory provide a way to measure for such a thing up to unbelievable accuracy. Want to guess what we have found so far?
See, for example, Ch. Eisele et al., Phys. Rev. Lett. v.103, p.090401 (2009):
Zz.