- #1
kankerfist
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I numbered each reagent and product so you can point and laugh accurately. Any tips would be awesome!
Is Converting a Secondary Amine to a Primary Amine Possible with This Route?
- Thread starter kankerfist
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SUMMARY
The discussion centers on the feasibility of converting a secondary amine to a primary amine using a specified synthetic route. Participants highlight that the proposed method may not yield significant results and suggest exploring alternative methods for this conversion. A key step mentioned involves creating a double bond, which should be followed by inducing a carbon-nitrogen double bond, particularly when conjugated with a benzene ring. Overall, the conversation emphasizes the importance of optimizing synthetic routes for better yields in amine conversions.
PREREQUISITES- Understanding of amine chemistry, specifically secondary and primary amines.
- Familiarity with organic synthesis techniques, including double bond formation.
- Knowledge of conjugation effects in aromatic compounds.
- Experience with reaction mechanisms involving carbon-nitrogen bonds.
- Research methods for converting secondary amines to primary amines.
- Learn about the mechanisms of double bond formation in organic synthesis.
- Investigate the effects of conjugation in aromatic systems on reaction outcomes.
- Explore alternative synthetic routes for amine transformations.
Chemistry students, organic chemists, and researchers focusing on amine synthesis and reaction optimization will benefit from this discussion.
I numbered each reagent and product so you can point and laugh accurately. Any tips would be awesome!
- #2
kankerfist
- 32
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I don't really need a full walkthrough, but if any you you guys spot a product/reagent 1-19 that you notice is right or wrong then please let me know :)
- #3
GCT
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The route seems excessive, you won't get a significant yield with it, the significance here is converting a secondary amine to a primary amine, you should search for methods that have to do with this topic in general.
You're approach of creating the double bond seems to be a good initial step, the next one would be to induce the carbon nitrogen double bond since it is more favorable when its conjugated with the Benzene ring.
You're approach of creating the double bond seems to be a good initial step, the next one would be to induce the carbon nitrogen double bond since it is more favorable when its conjugated with the Benzene ring.
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