Entropy and MIH, that's really rough. The dementia is the hardest to deal with. When my grandmother passed away, several years ago now, it was a bit of a blessing. She had been suffering from episodes of dementia, not just forgetfulness, but hallucinations (I think some of it was brought on by her addiction to percoset at the end...she was in such pain from another illness, and so old, that it was hardly worth putting her through withdrawal symptoms too to get her off the percoset, though her doctor was an idiot not to monitor her usage more carefully sooner). She had periods of lucidity in between, and those were the hardest, because she KNEW her mind was going and to her, that was far worse than her body failing. Mostly my aunts took care of her toward the end, but it would get to be too much for them at times, especially when she was really badly hallucinating and calling them at all hours of the night. When they stopped answering their phones because they couldn't take it anymore, I got the phone calls (she usually had a visiting nurse overnight, but those nurses aren't really equipped to handle mental illness like that, they can just ensure the patients are fed and have help getting to the bathroom if they need it and keep her from falling down stairs as she wanders the house, and my grandmother was so obnoxious to them, none of them lasted long). Anyway, there was nothing to be done. Sometimes if I called her back, that would help snap her out of it because there was some part of her that could still reason that if I knew where to call her, she must still be safely in her house even if she thought she was somewhere else.
So, it's rough. The more people you have around to share the burden, the better.