For an important chemical reaction, poikilotherms may have four to ten
enzyme systems that operate at different temperatures.
[4] As a result, poikilotherms often have larger, more complex
genomes than homeotherms in the same
ecological niche.
Frogs are a notable example of this effect, though their complex development is likely more important.
[5]
Because their metabolism is variable and generally below that of homeothermic
animals, sustained high-energy activities like powered
flight in large animals or maintaining a large
brain is generally beyond poikilotherm animals.
[6] The metabolism of poikilotherms favors strategies such as sit-and-wait hunting over chasing prey for larger animals with high movement cost. As they do not use their
metabolisms to heat or cool themselves, total energy requirement over time is low. For the same body weight, poikilotherms need only 5 to 10% of the energy of
homeotherms.
[7]