Why are Ni+2 and Cr+6 carcinogenic?

  • Thread starter Thread starter praeclarum
  • Start date Start date
AI Thread Summary
Cations, specifically nickel (Ni+2), are implicated in cancer mechanisms through several key processes. Nickel catalyzes reactions that produce reactive oxygen species, such as peroxide and superoxide, which can damage cellular components. Additionally, it inhibits the excision-repair of DNA, hindering the cell's ability to fix genetic damage. Furthermore, nickel contributes to gene silencing by increasing histone methylation and decreasing acetylation, which affects gene expression. This highlights the significant role of nickel in cancer development, revealing its multifaceted impact on cellular processes.
praeclarum
Messages
34
Reaction score
0
What is the mechanism by which these cations cause cancer?
 
Chemistry news on Phys.org
OK...so from this, the short answer appears to be: (1) Ni+2 catalyzes reactions that create reactive oxygen species (peroxide, superoxide). (2) inhibits excision-repair of DNA. (3) cause gene silencing (more methylation of histones, less acetylation).

Wow, I had no idea nickel did all this...
 

Thread 'Humidity of a saturated NaCl solution with anticaking additive'

I want to test a humidity sensor with one or more saturated salt solutions. The table salt that I have on hand contains one of two anticaking agents, calcium silicate or sodium aluminosilicate. Will the presence of either of these additives (or iodine for that matter) significantly affect the equilibrium humidity? I searched and all the how-to-do-it guides did not address this question. One research paper I found reported that at 1.5% w/w calcium silicate increased the deliquescent point by...
View full post »

Thread 'Resists for etching Aluminium with NaOH'

I'm trying to find a cheap DIY method to etch holes of various shapes through 0.3mm Aluminium sheet using 5-10% Sodium Hydroxide. The idea is to apply a resist to the Aluminium then selectively ablate it off using a diode laser cutter and then dissolve away the Aluminium using Sodium Hydroxide. By cheap I mean resists costing say £20 in small quantities. The Internet has suggested various resists to try including... Enamel paint (only survived seconds in the NaOH!) Acrylic paint (only...
View full post »

Similar threads

Why are some d-electron configurations more stable? (1st row)
Replies
4
Views
2K
Why Does Adding Strong Acid Change the Color of Metal Ion Solutions?
Replies
4
Views
1K
What is the name of the C=N+=C functional group?
Replies
1
Views
2K
Would Products Manufactured in U.S. be Safe from Carcinogens?
Replies
4
Views
2K
Determining the Ionic Radii of group 2 metal chlorides?
Replies
1
Views
2K
What are the dangers and ways to control danger of chromate
Replies
5
Views
2K
D2sp3 and sp3d2 Configurations of [Cr(NH3)6]3+ Ligand Complex
Replies
4
Views
4K
Does Back-Donation Decrease Down the Column for Cr(CO)6, Fe(CO)5, and Ni(CO)4?
Replies
1
Views
2K
Most dangerous chemicals?
Replies
46
Views
6K
Why are almost all polyatomic ions negative?
Replies
5
Views
2K

Hot Threads

Recent Insights

Back
Top