Usually, organisms don't evolve into a niche where there is already plenty of competition. Microbes have held their niche for about 3.5 billion years already, so they seem adapted well enough to compete with just about anything that comes along, with much disadvantage to the newcomer.
After all, humans have tried to exterminate/eliminate disease carrying microbes actively for a little over a century now. We won some impressive early victories with the development of artificial antibiotics (like penicillin, et seq.), but now the pendulum is swinging back into the microbes' favor since the microbes which survived the antibiotic onslaught have produced antibiotic-resistant strains which are rendering our medical arsenals pitifully ineffective. Having large scale outbreaks of infections return is not an exciting prospect for humanity, especially those in the developed world who have grown accustomed to antibiotic treatment providing quick and effective cures for such illnesses.