These days, it seems that we all rely on trial and error in order to predict the biochemical reactions of new drugs (say, we want a drug to be a ligand, but we have to rely on trial and error to predict whether or not it will actually fit - plus - we also need trial and error to determine the binding affinity of the ligand and how the binding affinity of the ligand compares to that of other ligands). And how does this also apply to toxicology? We have some theory to predict how toxic something *could* be. But our knowledge is still woefully incomplete, and no one's really convinced until we actually run clinical trials. Might knowledge of protein folding help with that? (of course, clinical trials will still always have to be run, but would they be significantly more convincing [and better targeted] if we had better knowledge of protein folding?