Zoology -- How a mosquito's CO2 detection system works?

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SUMMARY

The mosquito CO2 detection system relies on npa neurons, which are responsible for sensing carbon dioxide levels. Research indicates that similar mechanisms are observed in Drosophila melanogaster, where CO2 sensing neurons respond to high CO2 concentrations by opening ion channels due to increased intracellular acidity. This process leads to changes in membrane potential, although the specific mechanism for channel protein conformation changes at high pH remains unclear. The discussion highlights the shared characteristics between mosquitoes and Drosophila as dipteran flies.

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ORF
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Don't know about mosquitoes, but in Drosophilia, CO2 sensing neurons have been studied. Drosophila melanogaster is the best understood insect due to its status as a research model organism. Many, but not necessarily all of its receptors will probably be shared with mosquitoes. Both mosquitoes and Drosophila are diptern flies (only one pair of large wings).

In Drosophila, at least some CO2 sensing neurons seem to open ion channels in response to high CO2 levels by sensing intracellular acid levels.
The acidity of intracellular fluids will increase when exposed to high CO2 levels, triggering the channel to allow ions to cross the membrane leading to changes in membrane potential.

I have not found a description of a mechanism to change in channel protein conformation in high pH to underlie its opening.
 
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Hello

Thank you for your answer! :D

Regards,
ORF
 

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