The Evolution of Alcohol Tolerance: A Genetic Response to Human Consumption?

AI Thread Summary
The discussion centers on the genetic selection of alcohol tolerance among different populations, particularly in Europe and the Mediterranean. It raises questions about whether the craving for alcohol existed before its abundance or if it developed as a beneficial trait after alcoholic beverages became widely available. The argument suggests that if early humans who were less affected by alcohol had more offspring, it could have led to a population more vulnerable to alcohol's effects compared to sober groups. Conversely, if alcohol consumption provided advantages, it may have been selected for. The conversation also highlights that during Medieval Europe, alcohol was often safer to drink than water due to contamination, potentially leading to a selection pressure for higher alcohol tolerance. The role of light alcohol in hydration and its lower toxicity is mentioned, alongside the idea that European colonists passed this tolerance to their descendants in other regions. The genetic mechanism behind this tolerance, such as the enzyme alcohol dehydrogenase, is noted as a significant factor in understanding these dynamics.
Balloono
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As different individuals and races are very different comparing this trait, alcohol tolerance has/is probably under heavy genetic selection. As there isn't much alcohol outside human society, i wonder whether people craved alcohol by accident already before it became abundant or did that trait also become more prominent after alcoholic inventions. If the first one is true then possibly people less affected by alcohol gave more children but the whole group became vulnerable compared to sober human populations. If the latter is true then it was beneficial being able to consume alcohol and doing a lot of it. As i understand light alcohol (5%) does in fact hydrate you? and is less prone to becoming poisonous in other ways? Also why alcohol tolerance became strongest in Europe, Mediterranean? More suitable climate and more extensive trade relationships?
 
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Balloono said:
Also why alcohol tolerance became strongest in Europe, Mediterranean? More suitable climate and more extensive trade relationships?
Because everybody who drank the water instead of beer died of dysentry/cholera/typhoid/the dreaded lurg

If tea had been around in europe then people might have drunk tea instead like most east-asians
 
Balloono said:
As different individuals and races are very different comparing this trait, alcohol tolerance has/is probably under heavy genetic selection. As there isn't much alcohol outside human society, i wonder whether people craved alcohol by accident already before it became abundant or did that trait also become more prominent after alcoholic inventions. If the first one is true then possibly people less affected by alcohol gave more children but the whole group became vulnerable compared to sober human populations. If the latter is true then it was beneficial being able to consume alcohol and doing a lot of it. As i understand light alcohol (5%) does in fact hydrate you? and is less prone to becoming poisonous in other ways? Also why alcohol tolerance became strongest in Europe, Mediterranean? More suitable climate and more extensive trade relationships?

If I remember correctly in Medieval Europe alcohol was consumed quite frequently as it was safer to drink than the water in most places, whether this would be large enough effect to cause a selection pressure for Europeans to have a higher alcohol tolerance or not I don't know, I'll have a look for some papers on it. Obviously this tolerance would then be passed onto Americans, Australians etc. who were descended from European colonists.
 
Vagn said:
If I remember correctly in Medieval Europe alcohol was consumed quite frequently as it was safer to drink than the water in most places,
It was the only safe drink in europe from the Romans to the start of 20C

whether this would be large enough effect to cause a selection pressure for Europeans to have a higher alcohol tolerance or not I don't know,
Dying has quite a strong selection pressure - lookup Alcohol dehydrogenase
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
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