There are lots of loose ends, both in the Standard Model and elsewhere (
The Reference Frame: Why the Standard Model isn't the whole story).
Standard Model
It has lots of free parameters.
Gauge: 3
EF masses (Higgs-coupling eigenvalues): 9
EF mixing angles (Higgs-coupling eigenvector parameters): 4
Higgs mass and self-coupling: 2
Strong CP-violation phase: 1
Total: 19
Neutrino masses
Parameters:
Masses: 3
Mixing angle: 4
Total: 7, giving 26
If they are produced by Higgs interactions, they would require teeny-tiny ones, much smaller than the electron, up, and down ones. That's led to the "seesaw model", where neutrinos get their masses from both Higgs interactions and something that gives right-handed neutrinos masses near GUT masses. That gives estimates of neutrino masses that are fairly close to their observed values.
Supersymmetry
No direct evidence, but a lot of theoretical attractiveness. The easiest supersymmetry partners for the LHC to distinguish are the squarks and gluinos, but LHC observations have pushed lower limits on their masses up to about a TeV.
The Minimal Supersymmetric Standard Model has about 100 free parameters in addition to the Standard-Model ones, but many of them can be set to zero with bounds on Flavor Changing Neutral Currents and hypotheses like flavor independence. One can get as few as 5, as in the Constrained MSSM (CMSSM).
Despite the lack of direct evidence, there is indirect evidence in the form of the Higgs mass. It is about what one would predict from the CMSSM and similar models.
Higgs instability
A problem with the Standard Model at very high energies. A Higgs parameter would reverse sign, making the Higgs particle unstable. Supersymmetry would keep it from happening.
Gauge unification
This is from extrapolating the gauge coupling constants upward in energy. They converge, and the SM and various extensions of it have various amounts of convergence. The best is with the MSSM, at energies around 10
16 GeV, with only a few percent discrepancy:
Backreaction: Running Coupling Constants
[hep-ph/0012288] Beyond the Standard Model (In Search of Supersymmetry )
[1207.1435] Precision Unification in \lambda SUSY with a 125 GeV Higgs
SOFTSUSY Homepage – Hepforge: http://softsusy.hepforge.org/gaugeRun.eps (EPS), http://softsusy.hepforge.org/gaugeRunZoom.eps (EPS)
Some GUT's also predict mass unification of various particles at GUT energies, like for the bottom quark and the tau lepton.
Axion
This particle would suppress strong CP violation. Parameters:
Mass: 1
Interactions: 1 if universal, 3 if one for each SM gauge field
Proton decay
Isolated-proton decay, that is. Also includes decay of both protons and neutrons in nuclei. It has yet to be observed, but lifetime lower bounds approach what one would expect from MSSM gauge unification.
GUT nucleon decay has numerous possible channels, and observation of some of them can provide several constraints on GUT models.
Baryon asymmetry
Baryogenesis has 1 parameter, the baryon-to-photon or baryon-to-entropy ratio, around 10
-9, with no prospect of finding others. However, it is evidence of C and CP violation coupled with baryon-number violation.
It could have been generated at any time between GUT temperatures and electroweak symmetry-breaking temperatures, according to several theoretical models. Some predict GUT temperatures, some predict electroweak temperatures, and some predict somewhere in between.
Lepton asymmetry
Leptogenesis had contributed to the cosmic neutrino background, something that has yet to be detected. Ordinary neutrinos and antineutrinos in it would have abundances differing by about 10
-9, which seems VERY difficult to detect.
Dark matter
Only 1 parameter is well-established for it: its average density.
However, there are several attempts to detect WIMP dark matter, though none have been convincingly successful. They use several chemical elements as detector materials, meaning that one may be able to separate out several WIMP-nucleon interaction parameters.
Single nuclide: 1
Light and heavy nuclides with spin 0 or with spin-independent effects dominant: 2
With spin-dependent effects noticeable: 4
Thus giving as many as 5 parameters.
There is also the problem of the Fermi telescope's 130-GeV gamma-ray line observed near the direction of our Galaxy's center.
Dark energy
It currently has only 1 parameter: its density. However, "tracking" theories may give it some additional parameters; these theories make its density vary.
Inflaton
No "i" -- the hypothetical particle that produced cosmological inflation. Its energy scale is about 10
15 GeV, judging from the primordial-fluctuation amplitude, but additional primordial-fluctuation observations may give us additional parameters.
Gravity
Only 1 parameter: the Newtonian gravitational constant. It has the Planck energy scale, 10
19 GeV.
General-relativity alternatives like the Generalized Brans-Dicke theory have more parameters; GBD itself has 2.
The
hierarchy problem
Between the Standard-Model particle masses and GUT/Planck energy scales is a big gap.
Collecting the numbers:
Largest Standard-Model mass:
Higgs vacuum field value: 250 GeV
Neutrino seesaw: 10
15 GeV
Inflaton: 10
15 GeV
Gauge unification: 10
16 GeV
Gravity (Planck): 10
19 GeV