- #1
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Nernst equation:
[itex]\Delta[/itex]G = -2.3 RT log10 [itex]\frac{C_o}{C_i}[/itex] + zFV
R = 1.98x10-3 kcal/°K mole
T = absolute temperature in °K (37°C= 310 °K)
Co= concentration dissolved compound outside of cell
Ci= concentration dissolved compound inside of cell
z = the charge of the dissolved compound to be transported
F = Faraday constant 23 kcal/V mol
V = membrane potential in volt (V)
The question is:
What is the maximum concentration gradient that can be achieved when an uncharged molecule is pumped across the membrane with a [itex]\Delta[/itex]G of -12 kcal/mole?
I get the answer of [itex]\frac{C_o}{C_i}[/itex] = 1.3 which just doesn't sound right to me! :(
[itex]\Delta[/itex]G = -2.3 RT log10 [itex]\frac{C_o}{C_i}[/itex] + zFV
R = 1.98x10-3 kcal/°K mole
T = absolute temperature in °K (37°C= 310 °K)
Co= concentration dissolved compound outside of cell
Ci= concentration dissolved compound inside of cell
z = the charge of the dissolved compound to be transported
F = Faraday constant 23 kcal/V mol
V = membrane potential in volt (V)
The question is:
What is the maximum concentration gradient that can be achieved when an uncharged molecule is pumped across the membrane with a [itex]\Delta[/itex]G of -12 kcal/mole?
I get the answer of [itex]\frac{C_o}{C_i}[/itex] = 1.3 which just doesn't sound right to me! :(