- #1
Anand Wilson
- 6
- 0
what will be function of TERT,and shelterin complex protein in Neuron regeneration,is their any variant in telomere and telomerase between normal neuron and reprogramm neurons?
Anand Wilson said:Recently a paper published on april 2014,their is a extra telomeric function role while reprogramming of somatic cell
Telomeres are repetitive DNA sequences located at the ends of chromosomes that serve as protective caps. They are important for maintaining the stability and integrity of the chromosome. In neuron reprogramming, telomeres play a crucial role in regulating the lifespan of neurons and preventing premature aging.
During neuron reprogramming, telomeres undergo changes in length and structure. As neurons age, their telomeres naturally shorten. However, during reprogramming, telomeres can be elongated by the enzyme telomerase, which is activated by certain factors involved in the reprogramming process.
The length of telomeres is important for maintaining the health and lifespan of neurons. Shortened telomeres can lead to cellular dysfunction and even cell death. By elongating telomeres during the reprogramming process, the lifespan of reprogrammed neurons can be extended, potentially leading to more successful reprogramming outcomes.
Yes, telomeres can be manipulated to enhance neuron reprogramming. Researchers are currently exploring ways to activate telomerase and elongate telomeres in order to improve the efficiency and success of neuron reprogramming techniques.
As with any scientific technique, there are potential risks and limitations associated with telomere manipulation in neuron reprogramming. Some studies have shown that artificially elongating telomeres can lead to the development of cancer. Additionally, the long-term effects of telomere manipulation on reprogrammed neurons are still being studied and understood.