- #1
Cincinnatus
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I'm wondering if anyone is aware of any computational/theoretical work on solving the problem of describing the motion of a biological macromolecule in a cellular microdomain? This would have to mean setting up and solving a stochastic partial differential equation with boundary conditions defined by the geometry/permeability of the microdomain in question.
I've seen various papers on anisotropic diffusion but most are considering the case where there is no boundary. As an example, this paper comes to mind: Brownian Motion of an Ellipsoid (2006) Science Han et al.
http://www.sciencemag.org/cgi/content/abstract/314/5799/626
I've seen various papers on anisotropic diffusion but most are considering the case where there is no boundary. As an example, this paper comes to mind: Brownian Motion of an Ellipsoid (2006) Science Han et al.
http://www.sciencemag.org/cgi/content/abstract/314/5799/626