- #1
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Hello friends,
I am planning to do one new instance of benzoin condensation, with pyridine-4-carboxaldehyde as the carbonyl compound to receive, 2-hydroxy-1,2-dipyridin-4-ylethanone, the resultant benzoin compound. However I have some doubts as suggested in this website, since pyridine nitrogen is a good mesomeric effect provider; this is told to make the reactions harder. Would this pretreating works? First quaternizing the pyridine nitrogens by, say, methyl iodide, and after performing the benzoin reaction, remove them?
I am waiting for your comments, thank you.
chem_tr
I am planning to do one new instance of benzoin condensation, with pyridine-4-carboxaldehyde as the carbonyl compound to receive, 2-hydroxy-1,2-dipyridin-4-ylethanone, the resultant benzoin compound. However I have some doubts as suggested in this website, since pyridine nitrogen is a good mesomeric effect provider; this is told to make the reactions harder. Would this pretreating works? First quaternizing the pyridine nitrogens by, say, methyl iodide, and after performing the benzoin reaction, remove them?
I am waiting for your comments, thank you.
chem_tr