- #1
sameeralord
- 662
- 3
Hello everyone,
What I just read is for type 1 diabetes mellitus, it requires an environmental factor (eg virus) and genetic determinant that allows the B cells to be detected as non self. Now I'm not very familiar with autoimmune diseases. My question is why does a virus have to come and trigger the autoimmune destruction of B cells. If B cells are alreadly genetically non self, shouldn't the body start attacking them without a stimulus? Thank you
What I just read is for type 1 diabetes mellitus, it requires an environmental factor (eg virus) and genetic determinant that allows the B cells to be detected as non self. Now I'm not very familiar with autoimmune diseases. My question is why does a virus have to come and trigger the autoimmune destruction of B cells. If B cells are alreadly genetically non self, shouldn't the body start attacking them without a stimulus? Thank you