- #1
horsecandy911
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I've just finished reading through the generally well-written Wikipedia article on membrane potential:
http://en.wikipedia.org/wiki/Membrane_potential
I found almost everything to be clear, but one question is nagging at me. Why do changes in membrane permeability directly affect membrane potential? The Wikipedia article says:
I can understand why membrane permeabilities affect the equilibrium potential, but why should they affect the membrane potential instantaneously? Isn't the potential totally determined by the concentrations of charge inside and outside the membrane? Changing permeabilities by opening ion channels should shift the equilibrium potential and cause a gradual change in membrane potential in the direction of equilibrium, but they should not change the membrane potential immediately. Am I misunderstanding something? Thanks.
http://en.wikipedia.org/wiki/Membrane_potential
I found almost everything to be clear, but one question is nagging at me. Why do changes in membrane permeability directly affect membrane potential? The Wikipedia article says:
The more ions are permeant, the more complicated it becomes to predict the membrane potential. However, this can be done using the Goldman-Hodgkin-Katz equation or the weighted means equation. By simply plugging in the concentration gradients and the permeabilities of the ions at any instant in time, one can determine the membrane potential at that moment. What the GHK equations says, basically, is that at any time, the value of the membrane potential will be a weighted average of the equilibrium potentials of all permeant ions. The "weighting" is the ions relative permeability across the membrane.
I can understand why membrane permeabilities affect the equilibrium potential, but why should they affect the membrane potential instantaneously? Isn't the potential totally determined by the concentrations of charge inside and outside the membrane? Changing permeabilities by opening ion channels should shift the equilibrium potential and cause a gradual change in membrane potential in the direction of equilibrium, but they should not change the membrane potential immediately. Am I misunderstanding something? Thanks.