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Can high insulin make you fat directly?
I thought this was a very interesting study because it seems to question the usual relationship between insulin levels, insulin resistance and obesity:
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00453-6
http://www.sciencedaily.com/releases/2012/12/121204145549.htm
I thought this was a very interesting study because it seems to question the usual relationship between insulin levels, insulin resistance and obesity:
Hyperinsulinemia Drives Diet-Induced Obesity Independently of Brain Insulin ProductionHyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether insulin causes these phenomena or is a compensatory response has remained unsettled for decades...we provide genetic evidence that pathological circulating hyperinsulinemia drives diet-induced obesity and its complications.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00453-6
Could High Insulin Make You Fat? Mouse Study Says YesWhen we eat too much, obesity may develop as a result of chronically high insulin levels, not the other way around. That's according to new evidence in mice reported in the December 4th Cell Metabolism, a Cell Press publication, which challenges the widespread view that rising insulin is a secondary consequence of obesity and insulin resistance...The new study helps to solve this chicken-or-the-egg dilemma by showing that animals with persistently lower insulin stay trim even as they indulge themselves on a high-fat, all-you-can-eat buffet. The findings come as some of the first direct evidence in mammals that circulating insulin itself drives obesity, the researchers say.
http://www.sciencedaily.com/releases/2012/12/121204145549.htm
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