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zoobyshoe
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In my continuing research on seizures I came cross an article that goes into great technical depth. I'm wondering if anyone can read the following and expand and elucidate some of the biological terms.
"The cellular neurophysiological correlate of an interictal epileptiform discharge in single cortical neurons is the paroxysmal depolarization shift (PDS). The PDS is characterized by a prolonged calcium-dependent depolarization that results in multiple sodium mediated action potentials during the depolarization phase, and it is followed by a prominent after hypopolarization, which is a hyperpolarized membrane potential beyond the baseline resting potential. Calcium dependent potassium channels mostly mediate the afterhyperpolarization. When multiple neurons fire PDSs in a synchronous manner, the extracellular field recording would show an interictal spike.Calcium-dependent depolarization?
Calcium dependent potassium channels?
Sodium mediated action potentials?
"The cellular neurophysiological correlate of an interictal epileptiform discharge in single cortical neurons is the paroxysmal depolarization shift (PDS). The PDS is characterized by a prolonged calcium-dependent depolarization that results in multiple sodium mediated action potentials during the depolarization phase, and it is followed by a prominent after hypopolarization, which is a hyperpolarized membrane potential beyond the baseline resting potential. Calcium dependent potassium channels mostly mediate the afterhyperpolarization. When multiple neurons fire PDSs in a synchronous manner, the extracellular field recording would show an interictal spike.Calcium-dependent depolarization?
Calcium dependent potassium channels?
Sodium mediated action potentials?